Chronic Liver Disease and Cirrhosis, Donor Hepatectomy, Liver Transplant; Complications
Conditions
Keywords
Liver Transplantation, Magnetic Resonance Cholangiopancreatography, Liver donors
Brief summary
Living donor liver transplantation is widely accepted as an life-saving treatment for patients with end-stage liver diseases. Careful donor selection is essential to maximize the success and minimize the risk of postoperative complications in donors and recipients. Mapping of biliary anatomy is one of the critical assessments for donor selection and surgical planning ,Biliary reconstruction is considered as the "Achilles heel" of liver transplantation and adequate imaging assessment of biliary anatomy can largely benefit the biliary anastomosis. Preoperative imaging assessment of biliary anatomy is good for the selection of donors but may not indispensable for surgical planning and Intraoperative confirmative assessment of biliary anatomy with IOC was essential
Detailed description
Living donor liver transplantation is widely accepted as an life-saving treatment for patients with end-stage liver diseases. Careful donor selection is essential to maximize the success and minimize the risk of postoperative complications in donors and recipients. Mapping of biliary anatomy is one of the critical assessments for donor selection and surgical planning ,Biliary reconstruction is considered as the "Achilles heel" of liver transplantation and adequate imaging assessment of biliary anatomy can largely benefit the biliary anastomosis. Preoperative imaging assessment of biliary anatomy is good for the selection of donors but may not indispensable for surgical planning and Intraoperative confirmative assessment of biliary anatomy with IOC was essential
Interventions
DIAGNOSTIC_TESTMagnetic Resonance Cholangiopancreatography
Magnetic Resonance Cholangiopancreatography is being excluded from list of Investigation as part of Non inferiority trial
Sponsors
Institute of Liver and Biliary Sciences, India
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 55 Years
Healthy volunteers
No
Inclusion criteria
* All prospective voluntary healthy liver donor of age 18-55
Exclusion criteria
* Type C/D Portal vein anatomy * Left sided Gallbladder * Right Posterior Graft * Recipients undergoing Hepaticojejunostomy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To identify factors causing early biliary complications like type and number of arterial & biliary reconstruction, type of graft, number & size of Bile ducts in donor in both groups | 6 month of postop |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Donor biliary complications in both group | 1 month of postoperative period | Bile leak or strictures in Liver Donors |
| Identify Risk factors for early Biliary complications in recipients | till 6 months of Post operative period of Liver transplant | Identify Risk factors for early Biliary complications in recipients |
Countries
India
Contacts
CONTACTDr Atul Renjit, MBBS, MS, DNB
CONTACTDr Nilesh Sadashiv Patil, MCH
Outcome results
None listed