Kidney Cancers
Conditions
Keywords
Magnetic Resonance Imaging
Brief summary
In this study, high-resolution magnetic resonance imaging scans (MRI/mpMRI) were performed before surgical removal of the tumor and then compared with microscopic examinations of the tumor. Instead of looking at just one single area, the study compared many small, spatially correlated sections of the tumor-almost like creating a mini-map of the entire tumor.
Detailed description
A prospective single-center pilot study was performed on patients with solid renal tumors ≥2cm undergoing nephrectomy. Each patient underwent advanced preoperative 3.0T-mpMRI (including T2-weighted, pre-/postcontrast T1-weighted sequences, CS imaging, IVIM-DWI, and mapping). Tumor regions were jointly defined by a pathologist and radiologist. Identical Regions of Interest (ROIs) were assessed across all sequences to derive quantitative mpMRI parameters. Histopathology provided quantified regional fractions: viable tumor, fibrosis, hemorrhage, and cystic/necrotic components. Associations between these parameters were evaluated using Spearman's rank correlation and univariable linear regression at the regional level.
Interventions
DIAGNOSTIC_TESTmpMRI
Multiparametric MRI prior to nephrectomy
Sponsors
University of Zurich
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients with confirmed or suspected renal tumor with an approx. size of ≥ 2 cm who are scheduled for clinical MRI examination and surgical resection of the tumor * Informed consent as documented by signature (Informed Consent Form) * Patients ≥18 years of age
Exclusion criteria
* Women who are pregnant or breast feeding * Intention to become pregnant during the course of the study and lack of safe contraception * Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc. of the participant * Previous enrolment into the current study * Enrolment of the investigator, his/her family members, employees and other dependent persons * Patients with non-MRI compatible metallic or electronic implants, devices or metallic foreign bodies (cardiac pacemaker, shrapnel, cochlea implants, neurostimulator, or other non-MRI compatible implants). * Patients with known hypersensitivity reactions to MRI contrast agents will undergo the examination without application of a contrast agent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Viable tumor fraction | Baseline | Fraction of tumor that is viable |
Countries
Switzerland
Outcome results
None listed