PreDiabetes, Pre Diabetes, Prediabetic State
Conditions
Keywords
BMI, vo2 Max, glycemic control, Physical Activity, High-Intensity Interval Training
Brief summary
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. The objective of the study will be to find the effects of high intensity interval and continuous endurance training on glycemic control, BMI, Vo2 Max, pulmonary function and physical activity among prediabetic patients. Study design will be randomized control trial. Total 80 participants will be enrolled in study. The data will be collected from faculty of Riphah International University, Lahore. The study will be completed within 8 months after approval of synopsis. A simple random sampling will be used to assign the groups; group A and group B. Group A will be assigned high intensity interval training and group B will be assigned to continuous training.
Detailed description
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes. The objective of the study will be to find the effects of high intensity interval and continuous endurance training on glycemic control, BMI, Vo2 Max, pulmonary function and physical activity among prediabetic patients. Study design will be randomized control trial. Total 80 participants will be enrolled in study. The data will be collected from faculty of Riphah International University, Lahore. The study will be completed within 8 months after approval of synopsis. A simple random sampling will be used to assign the groups: group A and group B. Group A will be assigned high intensity interval training, and group B will be assigned to continuous training. Both interventions will be conducted over a 12-week period, with pre- and post-intervention assessments. Each exercise session constitutes a 5-minute warm up and finished with a 5-minute cool-down. Participants aged between 35 to 54 years with sedentary lifestyle, Stable medical condition, and stable body weight with changes less 3kg in the past 6 months will be included in this study. The study will exclude individuals with uncontrolled hypertension, history of heart disease, myocardial infarction and stroke and diagnosed type 2 diabetes, use of specific medications, severe obesity, high fasting blood glucose, previous history of respiratory problems, and smoking. Primary outcomes include changes in fasting blood glucose, HbA1c levels, and insulin sensitivity. Pre and post values of glucose level and FEV1, FVC and FEV1/FVC will be calculated. Secondary outcomes will assess BMI, VO₂ max through graded exercise testing, pulmonary function using spirometry, and physical activity levels measured by validated questionnaire of short form of IPAQ-SF. Data will be analysed using SPSS 24 and Shapiro wilks test will be applied to assess the normality of data. After assesing the normality of data paired sample/independent t test/ANOVA test will be applied to find which technique will be more beneficial for prediabetic patients.
Interventions
BEHAVIORALHigh-Intensity Interval Training
5 minutes warm up including walk * 30s fast stairs climbing * 60s slow walk down * Repeat 5 to 6 rounds * 5 minute stretching or slow walk (cool down)
BEHAVIORALContinuous Endurance Training
5 to 10 minute walking (warm up ) * 25 to 30minutes at 60 to 70 %continuous training * Continuous walk for 15 to 20 minutes. * 5 to 10 minutes stretching (cool down)
Sponsors
Riphah International University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
35 Years to 54 Years
Healthy volunteers
Yes
Inclusion criteria
* Sedentary lifestyle (Individuals reporting minimal structured physical activity e.g., \<30 minutes of exercise per week) . * Stable Medical Condition (No history of significant cardiovascular events, uncontrolled hypertension, or other major comorbidities). * Stable Body Weight (Stable body weight with changes less than 3 kg in the past 6 months).
Exclusion criteria
* uncontrolled hypertension * history of heart disease * myocardial infarction * stroke * Use of Specific Medications (Current use of insulin or other medications affecting glucose metabolism or exercise response) * Severe Obesity (Individuals with a BMI ≥ 40 kg/m) * High fasting blood glucose (Fasting blood glucose of \>100mg.dl-1) * Previous history of respiratory problems * Smoking
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fasting blood glucose | 12 weeks | Participants were instructed to fast overnight for 8 to 12 hours. FBG was measured using an automated glucose analyzer |
| Forced Vital Capacity | 12 weeks | Spirometry using devices like a digital spirometry will be used. Forced Vital Capacity (FVC) will be measured in liters (L) using spirometry. FVC represents the maximum volume of air that can be forcefully exhaled after a maximal inspiration. |
| Forced Expiratory Volume in One Second | 12 weeks | Forced Expiratory Volume in One Second (FEV₁) will be measured in liters (L) using spirometry. FEV₁ represents the volume of air exhaled during the first second of a forced expiratory maneuver. |
| FEV₁/FVC ratio | 12 weeks | The FEV₁/FVC ratio will be expressed as a percentage (%) and calculated from spirometric measurements to assess the degree of airflow limitation. |
| HbA1c | 12 weeks | HbA1c was assesed through high performance liquid chromatography |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Body mass index (BMI) | 12 weeks | Participants weight was measured using a calibrated digital scale with minimal clothing and no shoes height was measured using a wall mounted stadiometer with participants standing upright |
| IPAQ (short form) questionnaire | 12 weeks | International physical activity questionnaire is applicable for survey among 18 to 65 years to Assess the level of physical activity along different countries. It is developed in 2 Versions; first is long version (27 items), and the second is the short version (7 items). We will use IPAQ short version which consists of job, transport, domestic, and leisure time physical activity domains. Moderate and high-intensity walking and sitting time activities are addressed in this questionnaire |
| Maximal Oxygen Uptake (VO₂max) | 12 weeks | In this research VO2 Max will be measured through a submaximal 6 mint walk test |
Countries
Pakistan
Contacts
CONTACTMuhammad Iqbal Tariq, Phd
CONTACTMisdaq Batool, MS PT
PRINCIPAL_INVESTIGATORArjumand Bano, MS
Riphah International University
Outcome results
None listed