ECMO Outcomes, Hematopoetic Stem Cell Transplant, Malignancies, Hematologic, Respiratory Failure (Pediatric Patients), Solid Tumor Malignancies
Conditions
Keywords
Extracorporeal membrane oxygenation, Respiratory failure, Hematopoietic stem cell transplant, Pediatric Intensive Care Unit, Neoplasms
Brief summary
This was an observational study, with a descriptive and comparative portion. The descriptive analysis, a large single center experience, examined bleeding complications, infectious rates, and survival outcomes in patients under 18 years old with an underlying oncologic diagnosis and/or hematopoietic stem cell transplant on Extracorporeal membrane oxygenation (ECMO). In a small multicenter cohort, the comparative analysis evaluated survival outcomes in this population with respiratory failure in the presence and absence of ECMO. Children's Mercy Kansas City served as the ECMO cohort; Cincinnati Children's Hospital Medical Center served as the matched non-ECMO cohort.
Interventions
ECMO utilization in patient with malignancy and/or history of hematopoietic stem cell transplant.
Sponsors
Children's Mercy Hospital Kansas City
Children's Hospital Medical Center, Cincinnati
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
4 Weeks to 17 Years
Healthy volunteers
No
Inclusion criteria
* Less than 18 years old * Admitted to the PICU for respiratory failure (2015-2023) * Underlying oncologic diagnosis and/or hematopoietic stem cell transplant * Mechanical ventilation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of survival rates in pediatric patients with an underlying malignancy and/ or hematopoietic stem cell transplant in the presence and absence of ECMO support | Admission until hospital discharge, average of 46 days |
Outcome results
None listed