TEETH EXTRACTION
Conditions
Keywords
Titanium-Prepared Platelet-Rich Fibrin, Alveolar Ridge Preservation, Cone-Beam Computed Tomography,
Brief summary
Alveolar ridge preservation after tooth extraction is important for maintaining bone volume and facilitating future implant placement. Titanium-prepared platelet-rich fibrin (T-PRF) is an autologous platelet concentrate that may enhance soft and hard tissue healing through the sustained release of growth factors. However, clinical evidence regarding its effect on socket healing remains limited. The aim of this prospective randomized controlled clinical trial is to evaluate the effect of T-PRF on alveolar socket healing following tooth extraction. Participants requiring tooth extraction and subsequent implant placement are randomly assigned to either a T-PRF group or a spontaneous healing (control) group. Cone-beam computed tomography (CBCT) is used to evaluate socket healing volumetrically. The primary outcome is the percentage of socket fill and residual non-ossified socket volume after 3 months. Secondary outcomes include baseline socket volume and postoperative clinical healing. The findings of this study are expected to provide evidence regarding the effectiveness of T-PRF in enhancing alveolar socket healing and preserving ridge dimensions before implant placement.
Detailed description
Tooth extraction is commonly followed by physiological alveolar bone resorption, which may compromise subsequent implant placement. Alveolar ridge preservation techniques have been developed to minimize post-extraction dimensional changes. Titanium-prepared platelet-rich fibrin (T-PRF) is an autologous platelet concentrate prepared in titanium tubes without anticoagulants and has been proposed to enhance wound healing and bone regeneration through the sustained release of growth factors. This prospective randomized controlled clinical trial was conducted at the Department of Periodontology, Eskişehir Osmangazi University. Patients requiring tooth extraction followed by implant placement were screened according to predefined inclusion and exclusion criteria and provided written informed consent before participation. Participants were randomly allocated to either the T-PRF group or the spontaneous healing (control) group. In the intervention group, T-PRF was prepared from autologous venous blood using titanium tubes and placed into the extraction socket immediately after atraumatic tooth extraction. In the control group, extraction sockets were allowed to heal spontaneously without the use of any socket preservation material. All surgical procedures were performed by the same experienced operator, and postoperative care was standardized for all participants. Cone-beam computed tomography (CBCT) scans were obtained approximately 10 days after extraction (baseline) and again at 3 months before implant placement. Volumetric measurements were performed using dedicated imaging software by a blinded examiner. The primary outcome was the percentage of socket fill and residual non-ossified socket volume after 3 months. Secondary outcomes included baseline socket volume and clinical healing during the postoperative period. The results of this study will contribute to the clinical evidence regarding the effectiveness of T-PRF as a minimally invasive autologous biomaterial for enhancing extraction socket healing prior to implant placement.
Interventions
Autologous titanium-prepared platelet-rich fibrin (T-PRF) was prepared from the participant's venous blood collected into sterile titanium tubes without anticoagulant and centrifuged immediately after blood collection. The resulting fibrin clot was separated from the red blood cell layer, compressed into a membrane, and placed into the extraction socket immediately after atraumatic tooth extraction. The socket was then stabilized with sutures according to the study protocol.
Sponsors
Eskisehir Osmangazi University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Masking description
Radiographic volumetric measurements were performed by an outcome assessor who was blinded to the treatment allocation. No other study personnel were masked.
Intervention model description
Participants were randomly assigned to one of two parallel groups. The intervention group received titanium-prepared platelet-rich fibrin (T-PRF) following atraumatic tooth extraction, whereas the control group underwent spontaneous socket healing without any socket preservation material. Clinical and volumetric radiographic outcomes were assessed over a 3-month follow-up period.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged 18 to 65 years. * Systemically healthy individuals. * Indication for tooth extraction followed by implant placement. * Adequate bone volume for future implant placement without the need for advanced augmentation procedures. * Good oral hygiene (Plaque Index ≤1.5) * Ability and willingness to provide written informed consent.
Exclusion criteria
* Current smokers. * Pregnant or breastfeeding women. * Uncontrolled systemic disease or diabetes mellitus. * Use of medications known to affect bone metabolism. * History of head and neck radiotherapy or chemotherapy. * Acute infection, periapical lesions, alveolar bone pathology, or socket defects at the extraction site. * Severe periodontal destruction requiring extensive augmentation procedures. * Inability or unwillingness to attend scheduled follow-up visits.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of Socket Fill | 3 months after tooth extraction | Percentage of socket fill calculated using CBCT-based volumetric analysis by comparing the baseline socket volume with the residual non-ossified socket volume after healing. |
Countries
Turkey (Türkiye)
Contacts
STUDY_DIRECTORhakan özdemir, proffesor
Eskişehir Osmangazi University, Faculty of Dentistry, Department of Periodontology
Outcome results
None listed