Polycystic Ovarian Syndrome (PCOS), Reproductive Health
Conditions
Keywords
Kefir water, poly cystic ovarian syndrome, reproductive health
Brief summary
Polycystic ovary syndrome (PCOS) affect around 6-12% of women of age 18-25 years. Kefir contains bioactive compounds such as lactic acid bacteria, yeast, peptides, polysaccharides and organic acids and acts as a good probiotic source.
Detailed description
The target population were females between the ages of 18 and 25 years who have the history of amenorrhea or delayed periods, unusual weight gain, cyst in their ovaries, hormonal imbalance or thyroid issue. Once consent is given, participants were then be randomly assigned to receive the prescribed intervention or act as a control. (C0) Control group: Participants were only be subjected to use a regular calorie deficit diet plan (G1) Experimental group: Participants were advised to take water 250ml of water kefir per day in their mid-morning snack time for 2 months. At baseline, nutritional assessment based on weight and height, BMI, waist circumference, blood pressure, fasting blood glucose, lipid panels (HDL, LDL, total cholesterol, triglycerides), FHS Levels, LH levels, TSH levels was done after 8 weeks of intervention.
Interventions
OTHER(C0) Control group
Participants were subjected to use a regular calorie deficit diet plan
DIETARY_SUPPLEMENT(G1) Experimental group
Participants were advised to take water 250ml of water kefir per day in their mid-morning snack time for 2 months.
Sponsors
University of Lahore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
* Females of age 18-25 will be selected. * Females suffering from amenorrhea or cycle longer then 35days were selected. * Females with PCOS were selected. * Females with BMI 18.5-29.9 were selected in this research. * Females with thyroid issues were selected.
Exclusion criteria
* Pregnant and breast-feeding females were not included. * Those who smoke were not included. * Those who consume alcohol were not included. * Those suffering from endocrine diseases were not be included. * Those taking lipid- lowering drugs or blood pressure regulating medications were not be included. * Those taking antibiotics or medications related to PCOS treatment or vitamin-mineral or probiotics within 1 month prior to study inclusion.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Lipid Profile | 8 weeks | Blood lipid profile were obtained using fasting blood samples to determine serum total cholesterol, high-density lipoprotein cholesterol (HD L-C), low density lipoprotein cholesterol (LDL-C) and triglycerides. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| FSH (follicle stimulating hormone) | 8 weeks | Blood test will be done to check the reproductive health |
| LH (luteinizing hormone) | 8 weeks | Blood test to check the secretion of luteinizing hormone and how it triggers ovulation and stimulate testosterone production. |
Countries
Pakistan
Outcome results
None listed