Caffeine, Placebo - Control
Conditions
Brief summary
Evidence regarding the ergogenic effects of caffeine is well-established in young adults, but evidence in older adults remains scarce, particularly during dynamic resistance exercise. Therefore, this study investigated the effects of acute caffeine ingestion on upper- and lower-body muscular strength and endurance performance, as well as the influence of sex and CYP1A2 genotype, in healthy resistance training-naïve older adults.
Interventions
DIETARY_SUPPLEMENTCaffeine
Acute caffeine intake (3 mg/kg)
DIETARY_SUPPLEMENTPlacebo
Placebo (3 mg/kg maltodextrin)
Sponsors
University of Alcala
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Masking description
Statisian
Eligibility
Sex/Gender
ALL
Age
55 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 55 years. * Body mass index (BMI) lower than 25 kg/m². * Physically active subjects (≥150 min/week of moderate exercise). * Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise. * Participants capable of performing the tests.
Exclusion criteria
* History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism. * Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study. * Body mass index (BMI) ≥ 25 kg/m². * Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study. • Performing strenuous exercise within 48 hours prior to the tests. * Failing to replicate the same food intake on the two experimental days. * Consuming caffeine after 6 PM on the day prior to training or testing.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Mean velocity at different %1RM | Through study completion, an average of 3 weeks | Mean velocity at different %1RM |
| Number of repetitions performed during 1 set at 65%1RM until task failure | Through study completion, an average of 3 weeks | In bench press and back squat exercises |
| Bar velocity deplacement performed in 1 set at 65%1RM until task failure | Through study completion, an average of 3 weeks | In bench press and back squat exercises |
| handgrip and isometric mid-thigh pull tests | Through study completion, an average of 3 week | N generated |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| CYP1A2 polymorphism | Before the beginning of the trial | Using saliva sample and PCR |
| Mood state (tension, depression, anger, vigor, fatigue and confusion) | Through study completion, an average of 3 weeks | Participants graded a set of 29 items related to the mood on a Likert scale from 0 (not at all) to 4 (extremely) in reply to the question: How do you feel at this moment? to assess six scales: tension, depression, anger, vigor, fatigue and confusion. |
| Adverse effects | Through study completion, an average of 3 weeks | perception of power, endurance, energy and exertion, as well as heart, muscular and gastrointestinal discomfort |
Countries
Spain
Outcome results
None listed