Diabete Mellitus, Hyperlipidemia, Prediabetes
Conditions
Keywords
Diabete Mellitus, Prediabetes, Hyperlipidemia, lipid profile, date- cider vinegar
Brief summary
A common metabolic abnormality in hyperglycemic individuals, dyslipidemia is strongly linked to an increased risk of cardiovascular illness. This study looked at how date cider vinegar and 5:2 intermittent fasting affected the lipid profile and metabolic indices of hyperglycemic patients
Detailed description
The target population was adults between the ages of 35 and 65 years who are receiving outpatient care at a hospital or clinic with a diagnosis of either mild to moderate hypertension, dyslipidemia or pre-diabetes. Once consent was given, participants were then be randomly assigned to receive the prescribed intervention or act as a control. The intervention period was 12 weeks. Participants in the experimental groups received date cider vinegar supplementation, with one group additionally following the 5:2 intermittent fasting protocol. The control group received standard dietary advice without vinegar supplementation or fasting intervention. Participants were instructed to follow the assigned intervention daily according to the study protocol. Weekly follow-up visits were conducted to monitor dietary compliance, record self-reported adherence, and assess health outcomes including lipid profile, body weight,and blood pressure. Usual dietary intake was also monitored to ensure consistency and adherence to the intervention. At baseline, nutritional assessment based on weight and height, BMI, waist circumference, blood pressure, fasting blood glucose, lipid panels (HDL, LDL, total cholesterol, triglycerides), and dietary intake analysis were done. After 12 weeks of intervention all the measurements that were done again to compare the results pre- and post-intervention.
Interventions
DRUGControl Group (T 0 )
The control group received standard dietary advice without vinegar supplementation or fasting intervention.
DIETARY_SUPPLEMENTExperimental Group (T 1 )
Participants were advised to take 15 ml of Date Cider Vinegar (DCV) diluted in 1 cup (250ml) of water 15 minutes before breakfast and dinner daily for a duration of 3 months.
COMBINATION_PRODUCTExperimental Group (T 2 )
Participants were advised to follow 5:2 Intermittent Fasting (two non-consecutive fasting days per week) along with DCV intervention for a duration of 3 months. 15 ml of DCV was diluted in 1 cup of water and It was taken 15 minutes before breakfast and dinner daily.
Sponsors
University of Lahore
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
35 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* The inclusion criterion was target adults with both gender aged 35-65 years. * Adults with a diagnosis of mild to moderate hypertension * Mild hypertension (140-159/90-99 mm Hg) * Moderate hypertension (160-179/100-109 mm Hg) * Adults having mild to moderate alterations in lipid profile * Triglycerides: 150 to 499 mg/dL * LDL-C levels: Mild Alteration (130 to 159 mg/dL) and Moderate Alteration (160 to 189 mg/dL) * Adults with pre-diabetes (hbA1c= 5.6-6.4%) were used. * Patients were solicited from hospital.
Exclusion criteria
* Any Lactating and pregnant women were not included. * Any person allergic to citric acid. * Adults suffering from critical health conditions, including cancer.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Body Mass Index | 3 months | BMI was calculated by dividing weight (in kg) by the square of height (in meters). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood pressure | 3 months | Blood pressure measurements will be taken using an automated sphygmomanometer, with systolic pressure and diastolic pressure being measured while sitting after a 5-minute rest. The average of three readings were used for analysis. |
| Lipid Profile | 3 months | Total cholesterol, low-density lipoprotein cholesterol (LDL-C), triglycerides, and high-density lipoprotein cholesterol (HDL-C) levels were measured using enzymatic methods with commercial test kits. |
Countries
Pakistan
Outcome results
None listed