Acue Postoperative Pain
Conditions
Keywords
postoperative pain, ondasteron, intraperitoneal
Brief summary
This study, therefore, aimed to investigate the effect of intraperitoneal administration of ondansetron in combination to lidocaine for postoperative pain management in patients undergoing lower abdominal cancer surgery.
Detailed description
Postoperative pain relief is very important issue in any surgery. The common postoperative pain management is traditionally based on opioids (1,2). Considering opioids' adverse effects such as nausea, vomiting, sedation, drowsiness, and urinary retention, recently there is a lot of interest for f inding a safe and effective pain treatment after operation. Local anesthetics intraperitoneal instillation is recognized as a useful technique for postoperative pain management. They can reduce inflammatory response after surgery and produce analgesia by blocking neural transmission at the site of tissue injury (5). 5-HT3-antagonists, including ondansetron, are commonly used as anti-emetics to prevent and treat chemotherapy-induced vomiting and nausea \[7\]. Several studies have shown that 5-HT3-antagonists pose anti-inflammatory and analgesic properties, suggesting a potential clinical role in pain management.
Interventions
DRUGondansteron
intraperitonel irrigation
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Intervention model description
intraperitoneal irregation
Eligibility
Sex/Gender
ALL
Age
20 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* ASA I-II patients * scheduled for major lower abdominal cancer surgeries.
Exclusion criteria
* patients with known allergy to the study drugs, * significant cardiac, respiratory, renal or hepatic disease, * body mass index (BMI) ≥30 kg/m2; * allergy to study drugs * history of opioid use for pain management the time of enrolment or drug addiction, * who had used benzodiazepine chronically, * stroke or psychiatric disease that could affect the perception of pain.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| total morphine consumption | in the first 24 hours postoperative | total amount of morphine consumption in mg in the first 24 hours for analgesia |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| time of the first request of analgesia | first 24 hours postoperative | time between patients' extubation and first request of supplemental analgesia |
Countries
Egypt
Contacts
CONTACTshereen mamdouh kamal, professor
Outcome results
None listed