Comparison of Ketorolac Tromethamine 0.5%-Soaked Bandage Contact Lenses Versus Non-Medicated Bandage Contact Lenses on Postoperative Pain Control After Photorefractive Keratectomy

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07705763

Enrollment

Registered

2026-07-15

Start date

2026-08-01

Completion date

2026-10-31

Last updated

2026-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Photorefractive Keratectomy, Refraction Error

Keywords

Ketorolac tromethamine, Non-Medicated Bandage Contact Lenses, Postoperative Pain Control

Brief summary

Photorefractive keratectomy (PRK) is a well-established surface ablation procedure for the correction of refractive errors. Despite excellent visual and refractive outcomes, postoperative pain remains a significant concern, particularly during the first few days following surgery. This pain is primarily related to corneal epithelial removal, exposure of subepithelial nerve endings, and the subsequent inflammatory response. Effective pain management is therefore essential to enhance patient comfort, improve compliance with postoperative care, and increase overall surgical satisfaction. Therefore we will compare postoperative pain levels in patients undergoing PRK using ketorolac tromethamine 0.5%-soaked bandage contact lenses versus non-medicated bandage contact lenses.

Interventions

DEVICEKetorolac Tromethamine 0.5%-Soaked Bandage Contact Lenses

Soaking Bandage Contact Lenses in ketorolac prior to application may provide sustained drug release at the ocular surface, thereby enhancing postoperative pain control while reducing the need for repeated topical administration.Recent studies have suggested that ketorolac-soaked Bandage Contact Lenses may significantly reduce pain following Photorefractive Keratectomy without adversely affecting epithelial healing

DEVICEContact Bandage Lenses

Bandage contact lenses (BCLs) are routinely used after PRK to protect the corneal surface, reduce mechanical irritation from blinking, and promote epithelial healing

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

SUPPORTIVE_CARE

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

21 Years to 40 Years

Healthy volunteers

Inclusion criteria

* Participants selected to undergo photorefractive keratectomy for correction of refractive error after complete workup. * Participants willing to participate in the study after detailed explanation of the research purpose.

Exclusion criteria

* Known hypersensitivity to NSAIDs or ketorolac. * Presence of any systemic diseases affecting wound healing.

Design outcomes

Primary

Measure	Time frame	Description
Postoperative Pain	72 hours	Postoperative pain assessed using a standardized pain scoring system (e.g., Visual Analogue Scale) at 6, 24, 48, and 72 hours postoperatively.

Secondary

Measure	Time frame	Description
Epithelial Healing	72 hours	Time for epithelial healing

Countries

Pakistan

Contacts

CONTACTDr Hassan Abbas, MBBS

abbas.hassan97@gmail.com+923076781178

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 16, 2026