Enhancing Rehabilitation in Aging Study (ERAS)

Status

Not yet recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07704385

Enrollment

Registered

2026-07-15

Start date

2026-10-01

Completion date

2031-12-31

Last updated

2026-07-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adults

Keywords

Adults

Brief summary

Acute Intermittent Hypoxia (AIH) is a rehab approach attributed to serotonin. AIH signaling also occurs via adenosine, and the pathways inhibit each other. Increased neural adenosine in aging may stymie AIH plasticity. The hypothesis is pre-treatment with adenosine 2A receptor inhibition (A2AI) enhances AIH effects on motor plasticity in unaffected adults. AIH exposures will be paired with A2AI or placebo, with a 4-week washout. Primary outcome measures include inspiratory and grip strength.

Interventions

DRUGIstradefylline 20 mg

Participants will receive 20 mg istradefylline active treatment, followed by acute intermittent hypoxia

DRUGPlacebo

Participants will receive a methylcellulose capsule identical in appearance to the active treatment, followed by acute intermittent hypoxia

OTHERAcute Intermittent Hypoxia (AIH)

Short periods (\~1 minute) of breathing lower-oxygen gas, separated by periods (\~1 minute) of breathing normal oxygen air.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

40 Years to 79 Years

Healthy volunteers

Yes

Inclusion criteria

* Aged 40-79 years Non-smokers Ambulatory in the community Do not require assistance to complete activities of daily living

Exclusion criteria

* Restrictive or obstructive lung conditions Pregnancy Active respiratory infections Use of antibiotics in the last 4 weeks Symptomatic cardiac disease BMI \>35 kg/m2 Seizure disorder or progressive neurological condition Uses positive pressure mechanical ventilation when awake and upright, or oxygen assistance at any time

Design outcomes

Primary

Measure	Time frame	Description
Maximal Inspiratory Pressure	From enrollment to a 3-week follow-up.	Most negative pressure generated during a maximal inspiratory effort.
Maximal grip force	From enrollment to a 3-week follow up.	Highest tension generated by the flexor muscles of the hand during a maximal grip.

Contacts

CONTACTUshna Khan, MD

ushnakhan@ufl.edu352-273-6855

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 16, 2026