ABCG8, UGT1A1 and Gallstone Disease After Bariatric Surgery

ABCG8, UGT1A1 and Gallstone Disease After Bariatric Surgery: A Genetic Study

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07702630

Enrollment

270

Registered

2026-07-14

Start date

2026-10-01

Completion date

2029-03-01

Last updated

2026-07-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Bariatric Surgery, Cholecystectomy, Gallstone Disease, Genetics, Metabolic Surgery

Brief summary

The goal of this observational genetic case-control study is to learn whether two specific genetic variants in ABCG8 and UGT1A1 are associated with gallstone disease after bariatric surgery. The study includes adults who have previously undergone bariatric surgery. The main questions it aims to answer are whether the ABCG8 D19H variant and the UGT1A1 rs6742078 variant are associated with an increased risk of gallstone disease requiring cholecystectomy after bariatric surgery. Researchers will compare patients who underwent bariatric surgery and later had their gallbladder removed because of gallstone disease with patients who underwent bariatric surgery but did not develop gallstone disease or undergo cholecystectomy during follow-up. Participants will provide one blood sample for targeted genetic analysis and complete questionnaires about health, previous surgery, medication use, family history, and gastrointestinal quality of life. Relevant clinical information will also be collected from medical records.

Interventions

DIAGNOSTIC_TESTblood sampling

Targeted genetic analysis of the ABCG8 D19H variant and the UGT1A1 rs6742078 variant using a blood sample.

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Bariatric surgery

Exclusion criteria

* Gallstone disease or cholecystectomy prior to bariatric surgery

Design outcomes

Primary

Measure	Time frame	Description
ABCG8 carrier status	3 years	The primary outcome is the association between ABCG8 D19H carrier status and gallstone-related cholecystectomy after bariatric surgery. Cases are participants who underwent bariatric surgery and subsequently underwent cholecystectomy due to gallstone disease. Controls are participants who underwent bariatric surgery and did not undergo cholecystectomy or develop gallstone disease during follow-up. The association will be estimated by comparing genotype frequencies between cases and controls.

Secondary

Measure	Time frame	Description
Association Between UGT1A1 rs6742078 Carrier Status and Gallstone-Related Cholecystectomy After Bariatric Surgery	3 years	Association between UGT1A1 rs6742078 carrier status and gallstone-related cholecystectomy after bariatric surgery, estimated by comparing genotype frequencies between cases and controls.

Contacts

CONTACTBenjamin Petersen, M.D

benjamin.drejer.petersen@rsyd.dk+45 7918 5714

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 18, 2026