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NASA Exercise Prebreathe Study

Exercise Prebreathe Study in Healthy Adult Volunteers to Evaluate Risk of Decompression Sickness During Simulated Spacewalk Conditions

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07702539
Enrollment
30
Registered
2026-07-14
Start date
2026-07-13
Completion date
2027-02-27
Last updated
2026-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Decompression Sickness

Keywords

Decompression Sickness, Prebreathe Oxygen, Hypobaric Exposure

Brief summary

This study evaluates oxygen prebreathe protocols and exercise conditions to reduce risk of decompression sickness during simulated extravehicular activity. Healthy adult volunteers will undergo oxygen prebreathe followed by hypobaric chamber exposure with monitoring for symptoms and ultrasound detection of bubbles.

Interventions

PROCEDUREOxygen Prebreathe and Hypobaric Exposure

Prebreathe 100% oxygen followed by simulated spacewalk conditions in hypobaric chamber with exercise protocols.

Sponsors

Duke University
Lead SponsorOTHER
National Aeronautics and Space Administration (NASA)
CollaboratorFED

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* Non-smoking volunteers aged 30-60 years * Able to meet VO2 peak requirements (\>35 ml/kg/min males, \>30 ml/kg/min females)

Exclusion criteria

* Pregnancy * Lung disease, heart disease, hypertension, or diabetes * Musculoskeletal pain conditions * Requirement for regular medications such as analgesics

Design outcomes

Primary

MeasureTime frameDescription
Number of participants with Decompression SicknessUp to 6 monthsDecompression sickness will be recorded during Extravehicular Activity (EVA) simulation at 6.2 psia following a one-hour oxygen prebreathe while resting, performing light exercise or heavier exercise.

Contacts

PRINCIPAL_INVESTIGATORRichard Moon

Duke University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 15, 2026