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Different Endoscopic Approaches for Sphenoid Sinus

Different Approaches for Sphenoid Sinus

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07702188
Enrollment
60
Registered
2026-07-14
Start date
2026-08-01
Completion date
2028-09-01
Last updated
2026-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Endoscopic Sinus Surgery, Sphenoid Sinus

Brief summary

* Identification of the most effective approach for different lesion types * Correlation between approach and complication rates

Detailed description

The sphenoid sinus is one of the most anatomically complex and surgically challenging paranasal sinuses due to its deep location ,wide anatomical variation and proximity to critical neurovascular structures. Important structures are adjacent to the sphenoid sinus include the dura, pituitary, optic nerve, cavernous sinus, pterygoid canal and nerve, internal carotid artery, and cranial nerves III, IV, VI, V1, V2, which are vulnerable to injury with sphenoid disease. Wide anatomical variation such as Degree of Pneumatization , Septation Patterns , Sinus Size and Shape, Ostium Location ,Onodi Cells, Prominence or dehiscence of nearby structures. Therefore, surgeons must carefully select the extent of dissection to create a sphenoid opening that matches the patient's pathology while avoiding the risks associated with overly extensive openings and drilling, which may prolong healing and increase the likelihood of scarring and stenosis. Diagnostic nasal endoscopy procedures and imaging techniques are of great value for an early and precise diagnosis. Moreover, endoscopic sinus surgery is a safe and effective technique that allows a direct route to the sphenoid sinus. Because of its close vicinity to important and vulnerable structures of the skull base, delay in diagnosis and treatment can be potentially lethal. Sphenoid sinus lesions may range from mild, isolated inflammation to erosive tumors with cranial nerve deficits or cases requiring access to a pneumatized lateral recess . Additionally, conditions such as tumors, encephaloceles, mucoceles, and skull base lesions demand extra preoperative planning and careful technique selection.

Interventions

PROCEDUREendoscopic sinus surgery

Different approaches include: type I, sphenoid ostial dilation. type IIa, transnasal sphenoidotomy (sphenoidotomy without ethmoidectomy). type IIb, transethmoidal sphenoidotomy (sphenoidotomy with ethmoidectomy). type III, bilateral, common cavity sphenoidotomy, or "sphenoid drill-out;" type IV, transpterygoid approach, to expose the lateral sphenoid sinus recess. type V, sphenoid nasalization, completely removing the sphenoid sinus floor.

Sponsors

Assiut University
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Patients with sinonasal lesions involving sphenid sinus with or without skull base extension.

Exclusion criteria

* Severe comorbidities contraindicating surgery * malignant tumer extend beyond sphenoid sinus requiring open management

Design outcomes

Primary

MeasureTime frameDescription
To evaluate different endoscopic surgical approaches to the sphenoid sinus6 months* Complete lesion removal measured by post operative imaging ct * Complications examples Csf leakage Optic nerve injury (measured by visual acuity) * Carotid artery injury(bleeding) * Infection(meningitis csf examination if suspected)
To evaluate different endoscopic surgical approaches to the sphenoid sinus regarding: * Completence of lesion removal. * Complications. - Csf leakage - Optic nerve injury6 monthcomplications rate (csf leakage , optic nerve injury, carotid artery injury) * Recurrence * Endoscopic patency of sphenoid osteum and synechia formation

Countries

Egypt

Contacts

CONTACTDoaa Araby Mohamed, assistant lecturer
DoaaAraby9@aun.edu.eg+201119015094
CONTACTAhmed elrahman mohamed azzam, lecturer
ahmedazzam@aun.edu.eg01099978990
STUDY_DIRECTORmohamed modather, assistant professor

Assiut University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 15, 2026