Postoperative Hypocalcemia, Postoperative Hypoparathyroidism, Total Thyroidectomy
Conditions
Keywords
ionized calcium, blood gas analysis, total thyroidectomy, postoperative hypocalcemia, postoperative hypoparathyroidism, calcium monitoring
Brief summary
This prospective observational study aims to evaluate whether changes in ionized calcium levels measured by blood gas analysis during the preoperative, intraoperative, and postoperative periods can predict postoperative hypocalcemia in patients undergoing total thyroidectomy. Ionized calcium values obtained at predefined perioperative time points will be compared with postoperative biochemical and clinical hypocalcemia outcomes.
Detailed description
Postoperative hypocalcemia is a common complication after total thyroidectomy and may be associated with changes in calcium homeostasis and parathyroid function. Early identification of patients at risk for postoperative hypocalcemia may help guide postoperative monitoring and calcium replacement strategies. This prospective observational study included patients who underwent total thyroidectomy. Ionized calcium levels were measured by blood gas analysis at predefined perioperative time points, including the preoperative, intraoperative, and postoperative periods. Serum parathyroid hormone levels were also recorded. The study evaluated the relationship between perioperative changes in ionized calcium levels, postoperative parathyroid hormone changes, and the development of postoperative hypocalcemia. The primary objective was to determine whether perioperative ionized calcium changes can predict postoperative hypocalcemia after total thyroidectomy. Secondary objectives included evaluating the association between postoperative parathyroid hormone changes and postoperative hypocalcemia and assessing the diagnostic performance of ionized calcium measurements for predicting hypocalcemia.
Interventions
DIAGNOSTIC_TESTCalcium
Ionized calcium levels will be measured by blood gas analysis at predefined preoperative, intraoperative, and postoperative time points in patients undergoing total thyroidectomy.
Sponsors
Emrecan Deniz
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Inclusion criteria
* Patients aged 18 to 75 years * Present to the General Surgery Clinic of Başakşehir Çam and Sakura City Hospital * Diagnosis of thyroid disorders according to ICD code E07 * Scheduled to undergo total thyroidectomy due to toxic multinodular goiter, multinodular goiter, or papillary carcinoma * Provide informed consent to participate in the study.
Exclusion criteria
* Patients with preoperative parathyroid disorders associated hypocalcemia or hypercalcemia. * Patients with a history of previous thyroidectomy * Patients with a history of previous parathyroidectomy * Patients with a history of previous neck surgery. * Patients with chronic kidney disease. * Patients with a history of non-thyroid malignancy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ionized calcium | Preoperative baseline; postoperative 10 minutes; postoperative 6 hours | Ionized calcium levels will be measured by blood gas analysis at predefined preoperative and postoperative time points in patients undergoing total thyroidectomy. |
| parathormone levels | Preoperative baseline; postoperative 10 minutes; postoperative 6 hours; and postoperative 6 months | Serum parathyroid hormone levels will be measured in patients undergoing total thyroidectomy to evaluate the association between postoperative parathyroid hormone changes and postoperative hypocalcemia. |
Countries
Turkey (Türkiye)
Outcome results
None listed