Effects of Blood Gas Perturbations

Effects of Blood Gas Perturbations on Neuromuscular Function of the Diaphragm and Lower Limbs at Rest and During Exercise.

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07701603

Enrollment

Registered

2026-07-14

Start date

2026-08-31

Completion date

2029-12-31

Last updated

2026-07-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Brief summary

In this study, the effects of blood gas perturbations on neuromuscular function of the diaphragm and lower limbs at rest and during exercise will be investigated.

Interventions

OTHERGas perturbation

Participants will be breathing a gas mixture of either room air, or hypoxia, or hypercapnia, or a combination of both during 2h. This is followed by an all-out breathing exercise test against a small resistance, while still being in the respective gas condition.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 55 Years

Healthy volunteers

Yes

Inclusion criteria

* healthy * non.smoking * normal lung function * BMI: 18.5-29.9 kg/m2 * willing to adhere to study rules

Exclusion criteria

* Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep * Intake of medications affecting metabolism, the cardiovascular, the neuromuscular or the respiratory system, or sleep * Any metal or electronics inside of the body * Presence of cardiac pacemaker, implanted defibrillators or implanted neurostimulators * History of seizures or epilepsy * Tattoos on the stimulation sites * Previous enrolment in this study * For women: Pregnancy, breastfeeding, or intention to become pregnant during the study

Design outcomes

Primary

Measure	Time frame	Description
Diaphragm contractility	Continuously measured from 10 sec before until 10 sec after each stimulation. One stimulation lasts for approx. 1 sec	Diaphragm contractility measured before/during/following the gas exposures and the volitional respiratory muscle exercises using transdiaphragmatic and mouth pressure responses.

Contacts

CONTACTChristina M. Spengler, Prof.

christina.spengler@hest.ethz.ch+41 44 632 5007

PRINCIPAL_INVESTIGATORSpengler M. Christina, Prof.

Exercise Physiology Lab, Department of Health Sciences and Technology

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 15, 2026