Iron Deficiency Anaemia
Conditions
Keywords
Iron Deficiency Anemia, blood flow restriction
Brief summary
Preventing iron deficiency anemia is essential for strengthening adolescent health and ensuring their full development. Strategies such as improving nutrition, expanding the availability of iron-fortified products, implementing pharmacological prevention, and raising awareness play a crucial role in addressing this issue.
Detailed description
Anemia is a global public health problem affecting both developing and developed countries at all ages, with major consequences for human health as well as social and economic burden. Iron deficiency affects more than 2 billion people world wide, and iron deficiency anemia (IDA) remains to be the top cause of anemia. For decades, blood flow restriction (BFR), originating from Japan, has become one of the most popular techniques in physiotherapy. To perform the BFR technique, a controlled tourniquet is performed, generating a gradual mechanical pressure just below it, affecting blood flow (both arterial and venous) and generating a hypoxia in the restricted area. For the realization of the tourniquet, mechanical cuffs are used, which are inflated and regulate the pressure generated in the compression zone, although nylon or elastic cuffs are also used for the realization of the tourniquet.
Interventions
DEVICEaerobic exercise + blood flow restriction
Twenty five females will be subjected to supervised blood flow restriction combined with aerobic exercise program. participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes .A pressure of between 140 and 200 mmHg was applied using a sphygmomanometer cuff placed at the thigh of the BFR group. The pressure of the cuff was increased until the participants adapted to the restriction stimulus during the early phase of training, and this pressure was maintained used during the training protocol. The strap pressure was increased by 10 mmHg per week, such that it reached 200 mmHg by the end of 12th week. The pressure on the thigh strap was abruptly released after five completions of the exercise set.
PROCEDUREaerobic exercise
participated in 3 months exercise training protocol, which included three walking training sessions per week on a treadmill set at a speed 3 km/h. They experienced 3 session/week and each session include 5-10 minutes warming up and five training sets (each lasting 2 min) with a 1 min rest period between each exercise session and ended with 5-10 minutes cooling down.
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 25 Years
Healthy volunteers
No
Inclusion criteria
1. Hb more than 8 and less than 12 in females. 2. Age: 19-25 year. 3. BMI ranging from 25 to 29.9 kg/m2. 4. No existing inflammatory conditions including rheumatoid arthritis disorders of the lower extremities. 5. Physical activity level less than 150 min per week
Exclusion criteria
1. unstable hypertension, venous thromboembolism, hypercoagulable states, varicose veins, pregnancy, and hemophilia. 2. inherited or acquired red cell disorders (haemoglobinopathies). 3. acute or chronic infections (malaria, tuberculosis, HIV),. 4. severe anemia (Hb \<8 g/dL). 5. History of cardiovascular diseases. 6. Nutritional anemia (B12/folate) 7. Pregnancy. 8. Peripheral arterial disease. 9. Intermittent claudication. 10. Non smokers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| haemoglobin concentration | Baseline and 12 weeks |
| Serum ferritin level | Baseline and at 12 weeks |
| Haematocrit | Baseline and at 12 weeks |
| Red blood cell (RBC) count | baseline and at 12 week |
| Mean corpuscular volume (MCV) | baseline and at 12 week |
| Mean corpuscular haemoglobin (MCH) | baseline and at 12 week |
Secondary
| Measure | Time frame |
|---|---|
| Functional capacity assessed using the Incremental Shuttle Walk Test (ISWT) | baseline and at 12 week |
| Quality of life assessed using the SF-36 questionnaire | baseline and at 12 week |
| Estimated maximal oxygen consumption (VO₂max) derived from the ISWT | baseline and at 12 week |
Contacts
CONTACTnoha sameh donia, assisstant lecturer
Outcome results
None listed