Postoperative Cognitive Dysfunction (POCD)
Conditions
Keywords
target-controlled infusion, Manuel-controlled infüsion, propofol, Post-Operative Cognitive Dysfunction
Brief summary
The aim of this study is to investigate the effect of these two different intravenous infusion techniques \[manuel controlled infusion (MCI) and Target controlled Infusion( TCI)\] on POCD. To assess POCD, the Mini Mental State Examination (MMSE ) and the Montreal Cognitive Assessment (MoCA ) will be used. MoCA and MMSE have high sensitivity and specificity for identifying patients with mild cognitive impairment who perform within the normal range. In a study by Meng et al., comparing target-controlled infusion and manual infusion of propofol anesthesia during electroconvulsive therapy, the randomized, controlled trial showed no significant difference in postelectroconvulsive therapy changes in MoCA scores in either group; however, they reported improvement in MoCA scores after 6 electroconvulsive therapy treatments in the MCI group, while deterioration occurred in the TCI group. Researchers found no studies investigating the effects of both infusion methods in spinal surgery and their impact on cognitive function, and they planned to evaluate the effects of the groups in their study.
Interventions
DEVICEManuel controlled infusion group
infusion via manually controlled infusion pumps
Sponsors
Bursa Yuksek Ihtisas Training and Research Hospital
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Turkish language proficiency, * age (18-65 years), * American Society of Anesthesiologists (ASA) I-III score, * elective spinal surgery.
Exclusion criteria
* \- refusal to participate * central nervous system disorders, * use of antidepressants or antipsychotic medications, * alcohol or drug use, * illiteracy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Post-Operative Cognitive Dysfunction | preoperatively and 24 hours postoperatively at the patient's bedside | Montreal Cognitive Assessment (MoCA) scores Normally accepted threshold values: A score of 26 or higher on the MoCA (Montreal Cognitive Assessment) test For cognitive impairment: A decrease of at least 1-2 points on the MoCA is considered significant. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of intraoperative anaesthezic consumption | intraoperatıve | total propofol and total remifentanil |
Countries
Turkey (Türkiye)
Outcome results
None listed