Post-stroke Aphasia
Conditions
Keywords
post-stroke aphasia, supplementary motor area, transcranial direct current stimulation
Brief summary
This study aims to investigate the efficacy of transcranial direct current stimulation (tDCS) in patients with post-stroke aphasia (PSA) and to explore its potential neural mechanisms. The study will recruit PSA patients and provide them with 14 tDCS sessions over 7 days, along with speech therapy. Language Behavior Scale scores and resting-state functional MRI scans will be collected before and after the intervention. In addition, a retrospective comparison will be conducted of language function and resting-state fMRI changes in a group of PSA patients who received only speech therapy; these patients did not undergo any physical intervention but received only speech therapy. Changes in Language Behavior Scale scores and functional connectivity (FC) before and after treatment in the speech therapy-only group will be analyzed and compared with those in the tDCS intervention group.
Interventions
OTHERtranscranial direct current stimulation
As a non-invasive brain stimulation technique, tDCS offers advantages such as convenience, safety, and low cost. Its mechanism of action involves regulating neuronal activity in the brain by applying a weak direct current to the scalp.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Patients must be between 18 and 80 years of age * First stroke in the left hemisphere * Stroke onset within the past 12 weeks * Native Chinese speakers who were able to communicate normally prior to onset * Diagnosed with aphasia using the ABC scale * Right-handed * Informed consent obtained from the patient and family members
Exclusion criteria
* Time since stroke onset exceeds 12 weeks * History of psychiatric or neurological disorders * History of surgery for severe head trauma, brain tumors, or brain abscesses * Severe articulation disorders * Claustrophobia or implants incompatible with MRI * Inability to cooperate with language scale testing or fMRI scanning * History of previous stroke
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Aphasia quotient (AQ) | Baseline, immediately after all interventions have ended | The Aphasia Battery of Chinese (ABC) is a standardized Chinese adaptation of the Western Aphasia Battery (WAB). The Aphasia Quotient (AQ) is a composite score that reflects the overall severity of language impairment. The AQ score ranges from a minimum of 0 to a maximum of 100. Higher scores indicate better language function (i.e., less severe impairment). |
Secondary
| Measure | Time frame |
|---|---|
| rs-fMRI | Baseline, immediately after all interventions have ended |
Countries
China
Contacts
CONTACTJian Guan
Outcome results
None listed