Apical Periodontitis
Conditions
Brief summary
A randomized control trial which aim to compare the healing potential for the following treatment options for mature teeth with apical periodontitis: Group I: Conventional root canal treatment (CRT) Group II: Regenerative endodontic treatment (RET) using a blood clot scaffold Group III: RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)
Interventions
conventional root canal treatment with obturation
PROCEDURERegeneration
Regeneration using induction of bleeding
PROCEDURERegeneration with BMPs
RET using a blood clot scaffold loaded with recombinant human BMPs (rhBMPs)
Sponsors
Sara Tariq Elemam
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients aged 18-30 years * Healthy patients with no systemic diseases or known allergic reactions * Mature permanent molars diagnosed with pulp necrosis * Presence of a medium sized periapical lesion confirmed clinically and radiographically (PAI=3,4,5)
Exclusion criteria
* Patients with generalized chronic periodontitis * Presence of small periapical lesions (PAI=1,2) * Periodontal pockets \> 3 mm * Presence of systemic diseases or known hypersensitivity to any material used in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Healing in terms of volumetric change of lesion analyzed by CBCT | 1 year |
Countries
Egypt
Contacts
STUDY_DIRECTORShehab El Din Mohamed Saber, PHD
Faculty of dentistry Ain Shams University
Outcome results
None listed