Symptomatic Irreversible Pulpitis
Conditions
Keywords
Symptomatic Irreversible Pulpitis, Dexamethasone, Root canal Treatment, Intraoperative pain, Endodontics, local anesthesia, Inferior Alveolar Nerve Block
Brief summary
This study aims to determine whether giving a single dose of 4mg dexamethasone before root canal treatment can reduce the amount of pain patients experience during the procedure . Patients diagnosed with symptomatic Irreversible Pulpitis requiring endodontic treatment will be enrolled. Participants will receive either dexamethasone or placebo before treatment , and pain during the procedure will be measured using a Visual Analogue Scale (VAS) . The findings may help improve pain management strategies during root canal treatment .
Detailed description
Symptomatic irreversible pulpitis is a common cause of severe dental pain, and achieving adequate pain control during endodontic treatment remains a challenge despite the use of local anesthesia. Inflammatory mediators present in inflamed pulp tissues may reduce the effectiveness of local anesthetics , resulting in persistent intraoperative pain. Dexamethasone is a corticosteroid with potent anti-inflammatory properties that may reduce inflammatory mediator release and improve pain control . This randomized controlled clinical trial aims to evaluate the effectiveness of preoperative 4mg dose of dexamethasone compared with placebo in reducing intraoperative pain during endodontic treatment of teeth diagnosed with symptomatic irreversible pulpitis. Eligible participants will be randomly allocated to receive either dexamethasone or placebo before treatment . Standard local anesthesia and endodontic procedures will be performed for all participants . Intraoperative pain intensity will be assessed using a Visual Analogue Scale. The primary outcome will be the difference in intraoperative pain scores between the two groups. The results of this study may provide evidence regarding the role of preoperative dexamethasone as an adjunct for improving pain control during endodontic treatment .
Interventions
DRUGdexamethasone
participants receive 4mg dexamethasone administered via intraligamental infiltration followed by inferior alveolar nerve block before endodontic treatment of mandibular molars with symptomatic irreversible pulpitis
DRUGSaline (0.9% NaCl)
participants receive an equivalent volume of normal saline administered via intraligamental infiltration before root canal treatment for symptomatic irreversible pulpitis
Sponsors
Watim Medical & Dental College
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Intervention model description
This is a prospective ,randomized, placebo controlled , parallel-group clinical trial evaluating the effect of preoperative intraligamentary dexamethasone injection on the anesthetic success of 2% lidocaine during endodontic treatment of mandibular molars with symptomatic irreversible pulpitis . Sixty participants will be randomly allocated to receive either dexamethasone (4mg/ml) or sterile normal saline before inferior alveolar nerve block. The primary outcome is anesthetic success , defined as pain-free endodontic treatment without the need for supplemental anesthesia.
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Patients with pain VAS \>/= 6 2. Carious exposed mandibular molar with symptomatic irreversible pulpitis 3. Patients between ages 18-60 years 4. American Society of Anesthesiologists class I or II medical histories -
Exclusion criteria
1\. Patients with contraindications to local anesthesia solution or dexamethasone 2.Pregnant or breast-feeding females 4.Tooth having fused/extra roots, full coverage crowns, or poor periodontal status 5. Patients taking drugs which could affect the pain perception \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative pain intensity | Pain intensity assessed intraoperatively from initiation of access cavity preparation until completion of canal instrumentation during a single visit ( approximately 30-90 minutes). | intraoperative pain intensity measured using the Heft-parker Visual Analogue Scale following root canal treatment |
Contacts
CONTACTAyesha S Janjua, BDS
PRINCIPAL_INVESTIGATORDr.Ayesha S Janjua, BDS
Watim Medical and Dental College
Outcome results
None listed