Organ Donation After Circulatory Death
Conditions
Keywords
Predicting organ donation after circulatory death, DCD
Brief summary
The purpose of this study is to develop a new tool that uses information collected before life-sustaining treatments are withdrawn to better predict whether a patient will die within the time needed for organ donation to be possible. The tool created should help improve planning for organ donation and provide families and healthcare teams with more accurate information.
Interventions
None listed
Sponsors
University of British Columbia
Canadian Institutes of Health Research (CIHR)
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 19; 2. Eligible for DCD
Exclusion criteria
1. Complete high cervical spinal cord injury (C5 and above) 2. Pacemaker in situ 3. Tracheostomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To develop a clinically applicable model to predict dying duration in a cohort of patient eligible for donation after circulatory death | The models will be built to predict death within 30, 60 and 120 minutes | Specifically, we aim at assessing the predictive ability of blood-based brain biomarkers, optic nerve sheet diameter as measured by head computed tomography (CT) scans as a surrogate of intracranial pressure and autonomic dysfunction as reflected by abnormal heart rate variability (HRV) to predict the dying duration. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Comparison of the brain-to-heart model to existing models | The models will be compared for death within 30, 60 and 120 minutes | Our secondary aim will be to compare the created models with available models (e.g., DCD-N, UNOS, Wisconsin) and to physician gestalt |
Countries
Canada
Contacts
CONTACTRebecca Grey Clinical Research Coordinator
Outcome results
None listed