Evaluation of Photodynamic Therapy as an Adjunct to Non-surgical Treatment in Periodontitis in Smokers vs. Non-smokers

Comparison of Photodynamic Therapy vs. Non-surgical Periodontal Treatment in Patients Who Smoke vs. Non-smokers

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07697963

Enrollment

120

Registered

2026-07-13

Start date

2015-01-05

Completion date

2015-12-15

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Disease

Keywords

photodynamic therapy

Brief summary

Patients with moderate periodontal destruction underwent mechanical debridement of the pathological changes from the periodontal pockets in one of the randomly selected quadrants and in another, also randomly selected, quadrant. In addition to non-surgical debridement, photodynamic therapy was applied. This comparison between two treatment options was evaluated between subjects who smoke and non-smokers.

Interventions

PROCEDUREScaling and root planing plus placebo

Non-surgical treatment of periodontal pockets

COMBINATION_PRODUCTPhotodynamic therapy (PDT)

Photodynamic therapy was applied to a previously treated pocket with non-surgical therapy

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

18 Years to 65 Years

Healthy volunteers

Yes

Inclusion criteria

* at least two teeth with periodontal pockets up to 4 mm

Exclusion criteria

* less than two teeth with periodontal pockets

Design outcomes

Primary

Measure	Time frame
Periodontal pocket depth reduction	6 weeks

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 14, 2026