Short-Term Tocolysis in Preterm Labor

Prognostic Factors Affecting the Success of Short-Term Tocolysis in Preterm Labor

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07696858

Enrollment

100

Registered

2026-07-10

Start date

2026-08-01

Completion date

2027-07-01

Last updated

2026-07-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm Labor

Keywords

tocolysis, preterm labor

Brief summary

The aim of this study is to identify independent prognostic factors associated with the success of short-term tocolysis, defined as delivery delayed by at least 48 hours, in women with singleton preterm labor

Detailed description

All participants will receive short-term tocolytic therapy according to the unit protocol. * The choice of tocolytic agent (., Magnesium sulphate ) will be determined by the treating physician. * Tocolysis will be administered for a maximum duration of 48-72 hours. * Antenatal corticosteroids (Betamethasone amp 12mg once daily for 2days) will be administered to eligible participants to enhance fetal lung maturity. * Failure documented when there is efficient uterine contractions more 4/10mins each one lasts more than 40 seconds, and there was progressive cervical dilatation more 3cm

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Age from 18 to 45 years old. * Singleton Pregnancy * Gestational age between 24 and 34 weeks, confirmed by last menstrual period and/or first-trimester ultrasound. * Diagnosis of preterm labor, defined as Regular uterine contractions (≥4 in 20 minutes recorded in CTG) with a documented change in cervical dilation (e.g., from\<1 cm to ≥2 cm) or, in nulliparous women, a dilation of ≥2 cm * Intact membranes at the time of presentation.

Exclusion criteria

Established preterm labor (efficient uterine contractions 4/10mins each one lasts more than 40 Seconds recorded in CTG, with cervical changes (dilatation\>4cm, effacement\>80%)). * Evidence of chorioamnionitis or intrauterine infection. * Preterm premature rupture of membranes (PPROM). * Maternal medical disorders contraindicating tocolysis, such as severe preeclampsia, significant cardiac disease, or uncontrolled diabetes mellitus. * Contraindications to continuation of pregnancy, including placental abruption or placenta previa with bleeding. * Vaginal bleeding of unknown origin" as a specific exclusion criterion, as it may indicate abruption or other pathologies.

Design outcomes

Primary

Measure	Time frame
Successful short-term tocolysis, defined as postponement of delivery for at least 48 hours after initiation of tocolytic therapy	48 hours

Contacts

CONTACTMohamed Hussein Abdelatif Teleb Hussein Abdelatif Teleb, resident

mohamedhussein199819@gmail.com01022475295

Outcome results