Periodontitis
Conditions
Keywords
periodontitis, Adropin, gingival crevicular fluid, serum
Brief summary
This study aimed to evaluate gingival crevicular fluid (GCF) and serum levels of Adropin and tumor necrosis factor (TNF)-alfa in patients with periodontitis before and after non-surgical periodontal therapy.
Detailed description
Thirty periodontitis and thirty periodontally healthy individuals were enrolled in the study. Clinical periodontal measurements were recorded; periodontitis patients received non-surgical periodontal treatment, and GCF and serum samples were collected at baseline and at 6 weeks after treatment. Adropin and TNF-alfa were determined by ELISA.
Interventions
PROCEDURENonsurgical periodontal therapy
Nonsurgical periodontal therapy includes oral hygiene education and scaling and root planning approaches to eliminate microbial dental biofilm that is the primary etiology of periodontal diseases.
Sponsors
Giresun University
Aydin Adnan Menderes University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
27 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* having at least 20 natural teeth, excluding third molars * having no systemic disease * non-smokers * Diagnosed with periodontally health and periodontitis patients
Exclusion criteria
* having any systemic diseases * smoking * current pregnancy or lactation * a history of periodontal treatment in the past 6 months * using antibiotic, anti-inflammatory drugs or any other drugs within the past 6 months.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| 1. Adropin levels | Baseline and at 6 weeks after therapy | Changes in Adropin levels before and after periodontal therapy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| TNF-alfa levels | baseline and at 6 weeks after therapy | Changes in TNF-alfa levels before and after periodontal therapy |
Countries
Turkey (Türkiye)
Outcome results
None listed