Spinal Cord Injuries (SCI)
Conditions
Brief summary
The goal of this observational study is to evaluate whether increased lower extremity muscle tone can serve as an independent predictor of neurogenic detrusor overactivity (NDO) in adult patients (aged 18-80 years) with upper sacral spinal cord injury . The main questions it aims to answer are: Is increased lower extremity muscle tone independently associated with the presence of detrusor overactivity after adjusting for age, sex, injury level, injury type, and injury cause? Does the predictive value of muscle tone for detrusor overactivity differ across subgroups defined by injury level, injury severity, and time since injury? Researchers will compare patients with lower extremity hypertonia (Modified Ashworth Scale ≥ 1) to patients with normal muscle tone (Modified Ashworth Scale = 0) to see if muscle tone elevation independently predicts detrusor overactivity. Participants will not be asked to do anything beyond their routine clinical care, as this is a retrospective study that only collects data from existing medical records, including neurological examination results, Modified Ashworth Scale scores, and urodynamic study reports.
Interventions
None listed
Sponsors
Shengjing Hospital
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
16 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
Diagnosis of spinal cord injury confirmed by CT or MRI imaging Suprasacral spinal cord injury according to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI, 2011 revision) Age between 18 and 80 years Complete medical records, including detailed neurological examination, Modified Ashworth Scale assessment, and urodynamic study report
Exclusion criteria
Critical missing information in medical records or urodynamic reports Interval between Modified Ashworth Scale assessment and urodynamic study exceeding 2 weeks
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of Neurogenic Detrusor Overactivity Confirmed by Urodynamic Study | Baseline (At hospital admission) | Neurogenic detrusor overactivity (NDO) is defined as the presence of involuntary detrusor contractions during the filling phase of a urodynamic study, according to International Continence Society (ICS) standards. Urodynamic studies were performed as part of routine clinical care during the hospital admission. This outcome measures the presence or absence of NDO based on the urodynamic report. The result is reported as a binary outcome (present/absent). |
Contacts
CONTACTXue Jiang
CONTACTSiyan Lu
PRINCIPAL_INVESTIGATORXue Jiang
Rehabilitation Center of Shengjing Hospital, China Medical University
Outcome results
None listed