Ascending Aortic Aneurysm
Conditions
Brief summary
Ascending aortic aneurysms (AAAs) are serious conditions that can lead to aortic dissections or ruptures, carrying a high risk of mortality. Their pathophysiology is based on complex mechanisms involving inflammatory and metabolic processes, as well as alterations in mitochondrial function. The presence of a bicuspid aortic valve (BAV) or tricuspid aortic valve (TAV) significantly influences the progression and severity of aneurysms. Bicuspid aortic valve (BAV) patients often develop aortic aneurysms earlier, as early as age 40-50, whereas tricuspid aortic valve (TAV) patients generally present with a degenerative condition that appears later (after age 50). The objective of this study is to compare the inflammatory, metabolic, and transcriptomic signatures of myeloid cells and total aortic tissue between BAV and TAV patients. These analyses will help identify specific molecular mechanisms, potential biomarkers, and therapeutic targets. To ensure pathophysiological homogeneity, patients with aneurysms of genetic origin (Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, etc.) will be excluded.
Interventions
PROCEDUREAdditional blood samples
Additional blood sample are collected at the time of routine clinical blood sampling for recherche analyses.
PROCEDURECollection of discarded ascending aortic tissue
The aneurysmal portion of the ascending aorta (surgical specimen), which would otherwise be discarded, is collected for research purposes. No other tissue is collected, and the research protocol does not alter the surgical procedure.
Sponsors
Centre Hospitalier Universitaire Dijon
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Individuals who have given their consent * Patients with an ascending aortic aneurysm for which surgical replacement is indicated * Age \> 18 years * Scheduled surgery * Preoperative ultrasound confirmation of the heart valve architecture (bicuspid or tricuspid valve)
Exclusion criteria
* A person subject to a legal protective measure (guardianship, conservatorship) * A person subject to a judicial safeguard measure - A pregnant woman, a woman in labor, or a breastfeeding woman * Adults who are legally incapacitated or unable to give consent * Emergency surgical procedures * Patients with uncontrolled inflammatory or autoimmune conditions * Patients with a history of recent acute infection (within the last 3 months or still undergoing treatment) * Patients with a condition requiring immunosuppressants - Patients with a confirmed or suspected genetic aneurysm (Marfan syndrome, Loeys-Dietz syndrome, Ehlers-Danlos syndrome, etc.) * Patients with a history of cardiac surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory, metabolic, and transcriptomic markers of myeloid cells and aortic tissue | At the time of surgery |
Countries
France
Contacts
CONTACTComlan BLITTI
Outcome results
None listed