Corneal Topography and High Order Aberrations in Regular Contraceptive Pills

Corneal Topography and High Order Aberrations in Women on Regular Contraceptive Pills

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07693673

Enrollment

Registered

2026-07-09

Start date

2024-10-01

Completion date

2026-03-30

Last updated

2026-07-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cornea, Refraction Error

Keywords

cornea-contraceptive pills-high order aberrations

Brief summary

Effect of regular usage of contraceptive pills on corneal topography and corneal high-order aberrations

Detailed description

Comparing corneal topographic changes and corneal high-order aberrations for women planning to use oral contaceptive pills before and after the usage of the pills

Interventions

OTHERHormonal Contraception

Effect of usage of hormonal contraceptive pills on corneal topography and corneal high-order aberrations

DRUGCombined Oral Contraceptive (COC)

Participants who are prescribed combined oral contraceptive pills as part of routine clinical care will be observed. Corneal topography and tomography will be performed before starting treatment and after the follow-up period to evaluate changes in corneal parameters.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 40 Years

Healthy volunteers

Yes

Inclusion criteria

* Female participants aged 18-40 years. * Prescribed combined oral contraceptive pills as part of routine gynecological care. * Willing to undergo corneal topography/tomography before starting treatment and after 1 year. * No previous history of corneal disease or ocular surgery. * Able to provide informed consent.

Exclusion criteria

* Keratoconus or suspected corneal ectasia. * Corneal opacity, dystrophy, degeneration, or scarring. * Previous ocular surgery or significant ocular trauma. * Current contact lens use or recent contact lens use without adequate discontinuation period. * Active ocular surface disease or severe dry eye. * Glaucoma, uveitis, retinal disease, or other significant ocular pathology. * Diabetes mellitus, autoimmune disease, thyroid disease, pregnancy, or lactation. * Use of other hormonal therapy or systemic medications known to affect corneal parameters.

Design outcomes

Primary

Measure	Time frame
Change in K1 (D)	Baseline and 1 year
Change in K2 (D)	one year
Change in Kmax (D)	one year
change in corneal thickness (um)	one year

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 10, 2026