Hemophilia, Hemophilia A and B, Periodontitis
Conditions
Keywords
Hemophilia A, Hemophilia B, Periodontal Disease, Non-Surgical Periodontal Treatment, Oral Health-Related Quality of Life, Quality of Life
Brief summary
This study aimed to evaluate the effect of non-surgical periodontal treatment (NSPT) on oral health-related quality of life in patients with hemophilia using the Oral Health Impact Profile-14 (OHIP-14) questionnaire. In addition, clinical periodontal parameters and demographic characteristics before and after NSPT were assessed and compared with systemically healthy individuals. A total of 71 patients with hemophilia (60 with Hemophilia A and 11 with Hemophilia B) and 75 healthy individuals were included in the study and grouped according to their periodontal status. Demographic data and oral health-related behavioral characteristics were evaluated. Clinical periodontal parameters and OHIP-14 scores were recorded before treatment and at the sixth week after treatment. All collected data were analyzed statistically. The study aims to determine the relationship between periodontal treatment outcomes and oral health-related quality of life in individuals with hemophilia.
Interventions
PROCEDURENon-surgical periodontal treatment
Non-surgical periodontal treatment consisting of oral hygiene instruction, supragingival and subgingival scaling, and root planing performed in a single session. Clinical periodontal parameters and oral health-related quality of life were reassessed 6 weeks after treatment.
Sponsors
Karadeniz Technical University
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 64 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults aged 18 to 64 years. * Diagnosis of hemophilia A or hemophilia B (hemophilia group) or systemically healthy individuals/individuals with medically controlled systemic disease (control group). * Presence of at least 20 natural teeth, excluding third molars and teeth with orthodontic appliances. * Ability to provide written informed consent. * Willingness and ability to comply with study procedures
Exclusion criteria
* Presence of bleeding disorders other than hemophilia A or B. * Uncontrolled systemic diseases (e.g., uncontrolled diabetes mellitus or uncontrolled hypertension). * Use of medications known to affect periodontal tissues (e.g., calcium channel blockers, anticonvulsants, or immunosuppressive agents). * Fewer than 20 natural teeth. * Inability or unwillingness to provide informed consent or comply with study procedures.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Oral Health-Related Quality of Life (OHIP-14) Score | Baseline and 6 weeks after treatment | Change in Oral Health Impact Profile-14 (OHIP-14) score from baseline to 6 weeks after non-surgical periodontal treatment. Higher scores indicate poorer oral health-related quality of life. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Gingival Index (GI) | Baseline and 6 weeks after treatment | Change in gingival inflammation assessed using the Gingival Index. |
| Plaque Index (PI) | Baseline and 6 weeks after treatment | Change in dental plaque accumulation assessed using the Plaque Index. |
| Bleeding on Probing (BOP) | Baseline and 6 weeks after treatment | Change in bleeding on probing following non-surgical periodontal treatment. |
| Probing Pocket Depth (PPD) | Baseline and 6 weeks after treatment | Change in probing pocket depth measured using a periodontal probe. |
| Clinical Attachment Level (CAL) | Baseline and 6 weeks after treatment | Change in clinical attachment level following treatment. |
Countries
Turkey (Türkiye)
Outcome results
None listed