Preoperative Performance Indicators, Preoxygenation and Oxygen Reserve Relationship

Evaluation of the Relationship Between Preoperative Cardiopulmonary Performance Indicators (Hand Grip Strength and 6-Minute Walk Test) and Preoxygenation and Oxygen Reserve

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07688941

Enrollment

120

Registered

2026-07-07

Start date

2026-07-05

Completion date

2026-12-03

Last updated

2026-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Handgrip Strength Test, Preoxygenation, Sarcopenia

Brief summary

The goal of this observational study is to evaluate the relationship between preoperative cardiopulmonary performance indicators and preoxygenation efficiency along with oxygen reserve depletion in patients scheduled for elective surgery under general anesthesia. The main questions it aims to answer are: What is the relationship between Hand Grip Strength (HGS) and the time taken for end-tidal oxygen (EtO\_2) to reach 90% during preoxygenation? What is the relationship between the 6-Minute Walk Test (6MWT) distance and the Oxygen Reserve Index (ORI) depletion time during the apnea period? Participants will be asked to perform the following tasks during their preoperative and intraoperative care: Complete a 6-Minute Walk Test (6MWT) to determine preoperative functional capacity. Perform a Hand Grip Strength (HGS) test using a calibrated hand dynamometer to measure muscle strength. Undergo standardized preoxygenation with 100% oxygen via a tight-fitting face mask in the operating room while end-tidal oxygen (EtO\_2) and Oxygen Reserve Index (ORI) levels are continuously monitored.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Patients aged \>18 years ASA physical status I-III Scheduled for elective surgery under general anesthesia Voluntary written informed consent to participate in the study

Exclusion criteria

Severe COPD (Chronic Obstructive Pulmonary Disease) or restrictive lung disease NYHA Class III-IV Heart Failure Neuromuscular diseases Upper extremity pathologies affecting hand function (preventing HGS measurement) Orthopedic or neurological conditions preventing the 6-minute walk test (6MWT) Emergency surgeries

Design outcomes

Primary

Measure	Time frame	Description
Preoxygenation Efficiency (EtO_2 Time)	From the initiation of preoxygenation (0 seconds) until the EtO_2 values reach 90% (typically within 3 to 5 minutes before anesthesia induction)	The time taken for end-tidal oxygen (EtO\_2) to reach 90% during preoxygenation.
Oxygen Reserve Depletion Time (ORI Time)	From the cessation of preoxygenation/initiation of apnea until the ORI drops below 0.55	The time duration for the Oxygen Reserve Index (ORI) value to drop below 0.55.

Secondary

Measure	Time frame	Description
Preoperative Functional Capacity (6MWT)	Preoperative period	Total functional distance walked during the 6-minute walk test
Preoperative Muscle Strength (HGS)	Preoperative period	Muscle strength measured using a calibrated hand dynamometer (the highest value of three consecutive measurements using the dominant hand)

Contacts

CONTACTBetül Güven Aytaç

drbguven@hotmail.com+905073578351

Outcome results