Comparison of Green Tea, White Tea, and Chlorhexidine Oral Care for Prevention of Ventilator-Associated Pneumonia

Comparison of Chlorhexidine, Green Tea, and White Tea Oral Care for the Prevention of Ventilator- Associated Pneumonia in Mechanically Ventilated Patients

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07688057

Acronym

TEA-VAP

Enrollment

Registered

2026-07-07

Start date

2024-01-01

Completion date

2026-04-01

Last updated

2026-07-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical Ventilation, Oral Care, Ventilation Acquired Pneumonia

Keywords

VAP, Oral care, green tea, white tea, clorhexidine

Brief summary

This study was conducted to compare the effects of oral care performed using chlorhexidine (CHX), green tea, and white tea solutions on oral health, functional status, and the development of ventilator-associated pneumonia (VAP) in intensive care unit patients receiving mechanical ventilation (MV)

Detailed description

This prospective controlled interventional study included 63 mechanically ventilated adult intensive care unit patients. Participants were assigned to one of three oral care groups receiving chlorhexidine (CHX), green tea, or white tea according to the study protocol. Oral health was assessed using the Bedside Oral Examination (BOE) guide on days 1, 3, and 7. The primary objective was to compare the incidence of ventilator-associated pneumonia (VAP) among the study groups. Secondary outcomes included changes in oral health status and functional oral assessment during follow-up.

Interventions

PROCEDUREClorhexidine group

oral care using clorhexidine solution, green tea and white tea

PROCEDUREGreen Tea group

Participants received oral care using green tea according to the study protocol.

PROCEDUREwhite tea group

Participants received oral care using white tea according to the study protocol.

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Intervention model description

Participants were assigned to one of three parallel intervention groups receiving chlorhexidine, green tea, or white tea oral care throughout the study period.

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

1. Aged over 18 years 2. With no known allergies 3. Receiving invasive mechanical ventilator support 4. With a negative endotracheal aspirate culture on the day of ICU admission 5. Within the first 24 hours of mechanical ventilator support 6. Patients whose relatives agreed to participate in the study

Exclusion criteria

1. Patients with positive endotracheal aspirate cultures within the first 48 hours of intensive care admission, 2. Patients undergoing radiotherapy or chemotherapy, 3. Patients with contraindications for oral care, 4. Patients with a platelet count below 30,000/mm³, 5. Patients who cannot be positioned appropriately, 6. Patients with agitation severe enough to prevent the procedure from being performed

Design outcomes

Primary

Measure	Time frame	Description
ventilator associated pneumonia devolopment	7 days	Comparison of the incidence of ventilator-associated pneumonia among the chlorhexidine, green tea, and white tea oral care groups.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 9, 2026