PARKINSON DISEASE (Disorder)
Conditions
Keywords
Parkinson's disease, non-invasive stimulation, vibrotactile stimulation
Brief summary
Investigation on whether and how vibrotactile stimulation applied on the fingertips affects beta power in the subthalamic nucleus.
Detailed description
With a randomized order, two stimulation patterns are applied for one hour each on the fingertips of Parkinson's patients with deep brain stimulation, while periodically recording from subthalamic nucleus (STN) local field potentials (LFPs). The randomized vibrotactile stimulation (RVS) power is expected to reduce neuronal synchronization and LFP beta power. The All-on stimulation pattern is not expected to reduce neuronal synchronization and LFP beta power.
Interventions
DEVICEVibrotactile stimulation
Vibration patterns applied on the fingertips.
Sponsors
University of Colorado, Denver
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* The population to be enrolled will be between 18 and 85 years of * Have a diagnosis of idiopathic Parkinson's disease, determined by a movement disorders neurologist at the CU Movement Disorders Center * Has undergone deep brain stimulation surgery at the University of Colorado hospital
Exclusion criteria
* have severe sensory abnormalities of the fingertips such as vibratory urticaria * Patients that cannot clearly communicate with staff and speak English * Patients that are on psychoactive or narcoleptic medications, medications that affect brain function or alter EEG recorded activity (i.e., anticonvulsants, ADHD, depression, or anxiety medication) * Participation in another drug, device, biologic, or intervention trial concurrently or within the preceding 30 days.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Beta band power | At baseline (pre-intervention) and after 30 min of intervention | 13-30 Hz frequency band |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MDS-UPDRS Part III | At baseline (pre-intervention) and 1-hour of intervention | Movement disorder assessment for Parkinson's disease motor symptoms of the upper extremity. The scale is from 0 to 4 for the items in the MDS-UPDRS Part III, where 0 represents normal function (and 4 is worse). |
Countries
United States
Outcome results
None listed