Dental Implant Placement, Ozone Therapy
Conditions
Keywords
Ozone therapy, Primary implant stability, Insertion torque, Socket disinfection, Osseointegration
Brief summary
This randomized split-mouth controlled clinical trial aims to compare the effects of ozone and conventional implant site disinfection on primary and early secondary implant stability. Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will receive ozone disinfection at one implant site and conventional disinfection at the paired site according to a randomized allocation. Implant stability will be assessed immediately after implant placement using insertion torque and resonance frequency analysis (Implant Stability Quotient, ISQ), and secondary stability will be evaluated by ISQ measurements at the 3-month follow-up during healing abutment placement. The study will determine whether ozone disinfection improves implant stability during the early osseointegration period.
Detailed description
Primary implant stability is a key determinant of successful osseointegration and long-term implant survival. Various implant site disinfection methods have been proposed to reduce the microbial load before implant placement. Ozone possesses antimicrobial and biostimulatory properties and may improve the biological environment for implant healing compared with conventional implant site disinfection. The purpose of this randomized split-mouth controlled clinical trial is to compare ozone implant site disinfection with conventional implant site disinfection in terms of primary and early secondary implant stability. Systemically healthy adults requiring at least two dental implants in symmetrical or contralateral edentulous sites will be enrolled. According to a randomized split-mouth design, one implant site will receive ozone disinfection before implant placement, whereas the paired implant site will receive conventional disinfection. This design allows each participant to serve as their own control, thereby minimizing inter-individual variability. Primary implant stability will be assessed immediately after implant placement using insertion torque measurements and resonance frequency analysis (Implant Stability Quotient, ISQ). Secondary implant stability will be evaluated by resonance frequency analysis at the 3-month follow-up during healing abutment placement. All clinical procedures will be standardized and performed by experienced clinicians. The study aims to determine whether ozone implant site disinfection provides superior implant stability during the early osseointegration period compared with conventional implant site disinfection.
Interventions
PROCEDUREOzone Implant Site Disinfection
Before dental implant placement, the implant site assigned to the experimental intervention is disinfected using ozone according to the study protocol. In this randomized split-mouth design, each participant receives ozone disinfection at one implant site, while the paired contralateral or symmetrical implant site receives conventional disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ.
PROCEDUREConventional Socket Disinfection
Before dental implant placement, the implant site assigned to the control intervention is disinfected using the conventional disinfection protocol. In this randomized split-mouth design, each participant receives conventional disinfection at one implant site, while the paired contralateral or symmetrical implant site receives ozone disinfection. Implant stability is evaluated immediately after implant placement using insertion torque and resonance frequency analysis (ISQ), and again after 3 months using ISQ.
Sponsors
Zeliha Başak Çakır Erdil
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Participants are enrolled in a randomized split-mouth study design. Each participant receives both interventions at paired implant sites in symmetrical or contralateral edentulous areas. One implant site is assigned to ozone disinfection and the paired implant site to conventional disinfection before dental implant placement, allowing within-participant comparison.
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Adults aged 18 years or older. * Systemically healthy individuals requiring at least two dental implants. * Presence of symmetrical or contralateral edentulous sites suitable for dental implant placement. * Adequate bone volume for implant placement without the need for simultaneous bone augmentation. * Ability and willingness to provide written informed consent and comply with the study protocol.
Exclusion criteria
* Adults aged 18 years or older. * Systemically healthy individuals requiring at least two dental implants. * Presence of symmetrical or contralateral edentulous sites suitable for dental implant placement. * Adequate bone volume for implant placement without the need for simultaneous bone augmentation. * Ability and willingness to provide written informed consent and comply with the study protocol.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Primary Implant Stability (Insertion Torque) | Immediately after implant placement | Primary implant stability will be assessed immediately after implant placement by measuring insertion torque (Ncm). |
Countries
Turkey (Türkiye)
Outcome results
None listed