Non-hospitalised Men and Women Over 70 Years of Age
Conditions
Brief summary
Ageing of the general population may be a risk factor for various complications, including sarcopenia. Sarcopenia is a progressive loss of muscle mass and muscle strength, leading to a decrease in functional capacities. It affects between 0.7% and 16% of European adults over 70 years of age (1). Recent studies suggest that the faecal microbiota may be altered with ageing but also according to sarcopenic status. Furthermore, no study has currently published data on the relationship between salivary microbiota and sarcopenic status. The main hypothesis of this study is that a decrease in salivary microbiota richness could be associated with impaired handgrip strength in the ageing subject.
Interventions
PROCEDURESalivary and fecal microbiota sampling and muscle strength assessment
Collection of saliva and stool samples for microbiota analysis and assessment of handgrip strength in adults aged over 70 years.
Sponsors
University Hospital, Rouen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Male or female adult volunteer, over 70 years of age * Non-hospitalised * Having read and understood the information letter and signed the consent form * Affiliated with a Social Security scheme
Exclusion criteria
* Already included in an interventional drug clinical trial * Unable to understand and complete the questionnaires * Deprived of liberty by an administrative or judicial decision or protected adult subject (under guardianship, curatorship or judicial protection order) * Receiving antibiotic treatment or having received antibiotic treatment during the previous 3 months * Taking or having taken probiotics during the previous 3 months * Having undergone colonic lavage/bowel cleansing during the previous 3 months * Presenting one of the following situations likely to alter the microbiota: active cancer, eating disorders, exclusive vegetarian diet, history of digestive surgery * Having a cardiac pacemaker * Living in a nursing home for dependent elderly persons (EHPAD)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Salivary microbiota richness | baseline | Salivary microbiota richness (gene richness/alpha diversity) measured from saliva samples. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Fecal microbiota diversity | 15 days | Assessment of fecal microbiota diversity from stool samples and its association with maximal handgrip strength. |
| Title: Fecal microbiota richness | 15 days | Assessment of fecal microbiota richness according to handgrip strength and sarcopenia status. |
| Salivary microbiota diversity | 15 days | Assessment of salivary microbiota diversity from saliva samples and its association with maximal handgrip strength. |
| Fecal microbiota richness according to sarcopenia status | 15 days | Comparison of fecal microbiota richness between participants with and without sarcopenia. |
| handgrip strength | 15 days | Identification of microbiological and clinical factors associated with lower maximal handgrip strength. |
| Risk factors associated with low microbiota genomic diversity | 15 days | Identification of factors associated with reduced microbial gene richness and diversity in saliva and stool samples. |
Countries
France
Contacts
CONTACTProf. DECHELOTTE
CONTACTHERVET
Outcome results
None listed