Chronic Post-surgical Pain, Neuropathic Pain, Postoperative Pain After Thoracic Surgery, Thoracic Surgical Procedures
Conditions
Brief summary
Chronic post-surgical pain (CPSP) remains a common complication after thoracic surgery and may significantly impair patients' quality of life. Although the widespread adoption of video-assisted thoracic surgery (VATS) has reduced surgical trauma and improved postoperative recovery, a substantial proportion of patients still develop persistent pain. The EVATHO study is a multicenter prospective observational cohort designed to determine the prevalence of CPSP three months after VATS and to identify perioperative factors associated with its development. Adult patients undergoing thoracic surgery by VATS at Montpellier and Nice University Hospitals will be prospectively enrolled. Pain intensity, neuropathic pain characteristics, anxiety, depression, quality of life, and analgesic consumption will be assessed using validated questionnaires during the perioperative period and at 1 and 3 months after surgery. The results of this study may help identify patients at increased risk of CPSP and improve perioperative pain management strategies following thoracic surgery.
Interventions
None listed
Sponsors
University Hospital, Montpellier
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adult patients undergoing video-assisted thoracic surgery (VATS) for thoracic surgery
Exclusion criteria
* Age \<18 years * Adults under legal protection or unable to provide informed non-opposition * Patients unable to understand or complete the study questionnaires * Patients not affiliated with a French health insurance scheme. * Adults under legal protection, including judicial safeguard, guardianship, or curatorship. * Participation in another clinical study involving an ongoing exclusion period. * Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of participants with chronic post-surgical pain | 3 months after surgery. | Chronic post-surgical pain defined as a Brief Pain Inventory (BPI) average pain score greater than 3 at the 3-month postoperative follow-up. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative pain at 1 month after VATS | 1 month after thoracic surgery | Post-surgical pain defined as a Brief Pain Inventory (BPI) average pain score greater than 3 at the 1-month postoperative follow-up. |
| Visual Analogue Scale (VAS) pain score | Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery. | Pain intensity measured using the Visual Analogue Scale (VAS), with scores ranging from 0 (no pain) to 10 (worst imaginable pain). |
| Cumulative postoperative opioid consumption. | Postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery. | Total opioid consumption during the postoperative period as morphine milligram equivalents |
| Douleur Neuropathie 4 (DN4) score | Preoperative assessment, postoperative day 1, postoperative day 2, 1 month, and 3 months after surgery. | Neuropathic pain measured using the Douleur Neuropathique 4 (DN4) questionnaire. Scores range from 0 to 10, with scores greater than or equal to 4 indicating neuropathic pain. |
| Hospitalier Anxiety and depression Scale (HADS) anxiety score | Preoperative assessment, 1 month, and 3 months after surgery. | Anxiety measured using the hospital Anxiety and Depression Scale (HADS-A). Scores range from 0 to 21, with scores greater than or equal to 11 indicating clinically significant anxiety. |
| Hospital Anxiety and Depression Scale (HADS) depression score | Preoperative assessment, 1 month, and 3 months after surgery | Depression measured using the Hospital Anxiety and Depression Scale (HADS-D). Scores range from 0 to 21, with scores greater than or equal to 11 indicating clinically significant depression. |
| Brief Pain Inventory (BPI) pain interference score | 1 month and 3 months after surgery. | Pain interference with daily activities measured using the Brief Pain Inventory (BPI) interference subscale |
| Short Form-12 Physical component summary score | Preoperative assessment, 1 month, and 3 months after surgery. | Physical health-related quality of life measured using the Physical Component Summary (PCS) score of the Short Form-12 (SF-12) questionnaire. |
| Short form-12 Mental Component Summary score | Preoperative assessment, 1 month and 3 months after surgery | Mental health-related quality of life measured using the Mental Component Summary (MCS) score of the Short Form-12 (SF-12) questionnaire. |
Contacts
CONTACTBenjamin Bourdois, MD
CONTACTSophie Bringuier, MD
Outcome results
None listed