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Multicomponent Exercise and Frailty in Nursing Home Residents

Effects of a Multicomponent Exercise Program on Frailty in Institutionalized Older Adults: A Multicenter Controlled Study

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07686146
Acronym
BASE-Frail
Enrollment
66
Registered
2026-07-07
Start date
2021-11-30
Completion date
2022-12-31
Last updated
2026-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Balance Impairment, Fall Risk, Frailty at Older Adults, Functional Decline, Sarcopenia in Elderly

Keywords

multicomponent exercise, frailty, older adults, nursing homes, balance training, functional performance, fall prevention, physical therapy, institutionalizad elderly

Brief summary

Frailty is common among older adults living in nursing homes and increases the risk of falls, disability, and loss of independence. However, there is limited evidence on practical and feasible exercise programs adapted to this population. This study evaluated the effects of a multicomponent exercise program combining strength and balance training in residents aged 65 years and older. Participants were assigned to either an intervention group, which performed supervised exercise sessions twice a week for 8 weeks, or a control group, which continued their usual activities. The main outcome was frailty, measured using the Short Physical Performance Battery. Other outcomes included balance, functional independence, sarcopenia, fear of falling, and number of falls. This study was retrospectively registered.

Detailed description

Frailty is a multidimensional clinical condition highly prevalent among older adults living in institutional settings and is associated with increased risk of falls, disability, hospitalization, and mortality. Despite growing evidence supporting physical exercise interventions, there is still a need for structured, feasible, and clinically applicable programs specifically designed for nursing home residents. This study aimed to evaluate the effects of a multicomponent exercise program on frailty and related outcomes in institutionalized older adults. A multicenter, controlled, non-randomized design was used, including participants recruited from eight nursing homes. Participants aged 65 years and older were allocated by residential center to either an intervention group or a control group. The intervention group participated in the Balance and Strength Exercises (BASE) program, consisting of supervised sessions performed twice weekly for 8 weeks. Each session included a combination of strength and balance exercises with progressive levels adapted to individual capacity. The control group continued their usual care and routine activities. The primary outcome was frailty, assessed using the Short Physical Performance Battery (SPPB). Secondary outcomes included balance, measured with the Performance-Oriented Mobility Assessment (POMA); sarcopenia, measured with the Strength, Assistance with Walking, Rise from a Chair, Climb Stairs, and Falls Questionnaire (SARC-F); functional independence, measured with the Barthel Index; fear of falling, measured with the Short Falls Efficacy Scale-International (Short FES-I); and the number of falls occurring during the study period. Assessments were conducted at baseline, immediately after the intervention (8 weeks), and at follow-up (20 weeks). The study evaluated both the immediate effects of the intervention and the persistence of outcomes after cessation. This study was retrospectively registered following completion of data collection.

Interventions

BEHAVIORALMulticomponent Exercise Program (BASE)

A supervised multicomponent exercise program including strength and balance training, performed twice weekly for 8 weeks. Each session lasted 30-40 minutes and included warm-up, strength exercises, and progressively adapted balance tasks based on individual capacity.

OTHERUsual Care

Participants continued their usual care and routine physical activities provided by the nursing homes without additional structured intervention.

Sponsors

Escoles Universitaries Gimbernat
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Masking description

No blinding was used due to the nature of the intervention.

Intervention model description

Participants were allocated by residential center to either an intervention group or a control group in a non-randomized parallel design. The intervention group received a multicomponent exercise program, while the control group continued usual care.

Eligibility

Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Aged 65 years or older * Living in a nursing home * Ability to walk at least 10 meters (with or without assistive devices) * Mini-Mental State Examination (MMSE) score ≥19

Exclusion criteria

* Neurodegenerative diseases * Advanced dementia * Parkinson's disease * Hemodynamic instability * Lower limb fractures under rehabilitation within the past year

Design outcomes

Primary

MeasureTime frameDescription
Frailty assessed by the Short Physical Performance Battery (SPPB)Baseline to 8 weeksFrailty was measured using the Short Physical Performance Battery (SPPB), which includes assessments of balance, gait speed, and chair rise performance. Total scores range from 0 to 12, with higher scores indicating better physical performance.

Secondary

MeasureTime frameDescription
Balance assessed by the Performance-Oriented Mobility Assessment (POMA)Baseline, 8 weeks, and 20 weeksBalance was measured using the Performance-Oriented Mobility Assessment (POMA), which evaluates static and dynamic balance as well as gait performance. Total scores range from 0 to 28, with higher scores indicating better balance and mobility.
Sarcopenia assessed by SARC-FBaseline, 8 weeks, and 20 weeksSarcopenia was measured using the Strength, Assistance with Walking, Rise from a Chair, Climb Stairs, and Falls Questionnaire (SARC-F), a self-reported screening tool for sarcopenia risk. Total scores range from 0 to 10, with higher scores indicating a greater risk of sarcopenia.
Functional independence assessed by the Barthel IndexBaseline, 8 weeks, and 20 weeksFunctional independence was measured using the Barthel Index, which assesses the ability to perform activities of daily living, including feeding, bathing, dressing, toileting, mobility, and stair climbing. Total scores range from 0 to 100, with higher scores indicating greater functional independence.
Fear of falling assessed by Short FES-IBaseline, 8 weeks, and 20 weeksFear of falling was measured using the Short Falls Efficacy Scale-International (Short FES-I), which assesses concerns about falling during everyday activities. Total scores range from 7 to 28, with higher scores indicating greater fear of falling.
Number of fallsThroughout the 20-week study periodFalls were measured as the total number of falls recorded during the study period using incident reports from the participating nursing homes. Higher values indicate a greater frequency of falls.

Countries

Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 8, 2026