Periodontitis (Stage 3)
Conditions
Brief summary
This study was planned on the basis of the hypothesis that 'food supplements containing collagen will support the clinical effectiveness of non-surgical periodontal therapy'. In this context, the aim of the study is to investigate the therapeutic efficacy of collagen-containing food supplement as a host modulation agent in the non-surgical periodontal treatment of individuals with stage 3-4 periodontitis in a clinical and biochemical manner in a comprehensive manner. Initial day: Anamnesis, diagnosis and index measurements 2 days later, collection of serum samples from the patient, oral hygiene training and straightening of the whole mouth root surface and cleaning of the whole mouth tooth surface The next day, full mouth scalling and root planing are closed with the second session and tablets are started. End of 2nd month: Periodontal index measurement and oral hygiene training Collecting serum and tissue samples 2 days later End of 6th month Periodontal index measurement and oral hygiene training Collecting serum and tissue samples 2 days later
Interventions
DIETARY_SUPPLEMENTCollagen hydrolyzed peptides
Collagen supplements will not be given in the placebo group.
placebo will be given.
Sponsors
Hatice Yemenoglu
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* 18 - 60 age * stage 3-4 periodontitis
Exclusion criteria
* Patients who smoke more than 10 cigarettes a day * Patients using immunosuppressive, oral contraceptive, bisphosphonate drugs * Patients who are during pregnancy or lactation * Having undergone periodontal treatment in the last 6 months, having used antibiotic anti-inflammatory medication in the last 4 weeks * The presence of any autoimmune disease, osteoporotic disease or cancer disease * Patients with renal and hepatic insufficiency * Patients with thyroid dysfunction * The presence of active infectious diseases(acute hepatitis, tuberculosis, AIDS) * Chronic drug use affecting periodontal tissues(cyclosporine A, Phenytoin) * Intake of antioxidant supplements
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| probing pocket depth | baseline, 1st month and 3rd month | The distance between the gingival margin and the pocket base was measured in millimeters. |
| clinical attachment loss | baseline, 1st month and 3th month | The distance from the enamel-cementum junction to the pocket base was measured in millimeters. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| assessment of interleukin-1 beta levels | baseline, 1st month and 3th month | Serum interleukin-1 beta levels were measured biochemically. |
| assessment of matrix metalloproteinase-8 (MMP-8) levels | baseline, 1st month and 3 th month | Matrix metalloproteinase-8 (MMP-8) levels in gingival crevicular fluid were measured biochemically. |
Countries
Turkey (Türkiye)
Outcome results
None listed