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Short-Axis Versus Long-Axis Ultrasound-Guided Peripheral IV Cannulation in Adults

Comparison of Short-Axis Versus Long-Axis Approach for Ultrasound-Guided Peripheral Intravenous Cannulation: A Randomized Controlled Trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07683611
Enrollment
222
Registered
2026-07-06
Start date
2023-11-07
Completion date
2024-05-07
Last updated
2026-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Peripheral Venous Catheterization

Keywords

Ultrasound-Guided Peripheral Intravenous Cannulation, Short-Axis Out-of-Plane Approach, Long-Axis In-Plane Approach, Peripheral Intravenous Access, Interventional Ultrasonography

Brief summary

This randomized study compared two ultrasound-guided techniques for placing a peripheral intravenous cannula in adults aged 20 to 60 years who required intravenous access. Participants were assigned equally to either the short-axis out-of-plane approach or the long-axis in-plane approach. The study evaluated whether the techniques differed in successful cannulation. It also compared cannulation time, number of attempts, and immediate complications, including arterial puncture, extravasation, and haematoma.

Detailed description

This single-centre, parallel-group randomized controlled trial was conducted in the Department of Anaesthesiology at Medical Teaching Institution-Lady Reading Hospital, Peshawar, Pakistan. A total of 222 eligible adults requiring peripheral intravenous access were enrolled through consecutive sampling. Participants were randomized in a 1:1 ratio using a computer-generated sequence. In the short-axis group, the ultrasound probe was positioned perpendicular to the target vein to obtain a transverse image, and the needle was advanced using an out-of-plane technique. In the long-axis group, the probe was positioned parallel to the vein to obtain a longitudinal image, and the needle was advanced in plane while maintaining visualization of the needle tip. Experienced anaesthesiologists performed all procedures. Cannulation was considered successful when the catheter advanced without resistance, blood returned freely into the hub, and saline could be flushed without local swelling. The primary outcome was successful peripheral intravenous cannulation. Secondary outcomes included cannulation time, number of attempts, and immediate complications comprising arterial puncture, extravasation, and haematoma. No delayed follow-up outcomes were assessed.

Interventions

PROCEDUREShort-Axis Out-of-Plane Ultrasound-Guided Cannulation

The ultrasound probe was positioned perpendicular to the target vein to obtain a transverse image. A peripheral intravenous cannula was inserted by advancing the needle using the out-of-plane technique under real-time ultrasound guidance.

PROCEDURELong-Axis In-Plane Ultrasound-Guided Cannulation

The ultrasound probe was positioned parallel to the target vein to obtain a longitudinal image. A peripheral intravenous cannula was inserted by advancing the needle in plane while maintaining visualization of the needle tip under real-time ultrasound guidance.

Sponsors

Lady Reading Hospital, Pakistan
Lead SponsorOTHER_GOV

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

Participants were randomly assigned in a 1:1 ratio to one of two parallel groups. One group received ultrasound-guided peripheral intravenous cannulation using the short-axis out-of-plane approach, while the other received the long-axis in-plane approach. Each group included 111 participants.

Eligibility

Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
No

Inclusion criteria

* Men and women aged 20 to 60 years * Required peripheral intravenous access

Exclusion criteria

* Body mass index of 30 kg/m² or greater * Infection at the intended cannulation site * Upper-limb deformity * Previous venous thrombosis * Refusal to participate

Design outcomes

Primary

MeasureTime frameDescription
Successful Peripheral Intravenous CannulationImmediately following the assigned cannulation procedureCannulation was considered successful when the catheter advanced without resistance, blood returned freely into the hub, and saline could be flushed without local swelling. The outcome was recorded as successful or unsuccessful.

Secondary

MeasureTime frameDescription
Cannulation Timeuring the assigned cannulation procedureTime required to achieve successful peripheral intravenous cannulation, measured in seconds.

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 7, 2026