Trauma Molecular Processes

Study of Pathological and Regenerative Molecular and Cellular Processes Triggered After Traumatic Brain Injury: Analysis of Biopsy Specimens

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07683169

Acronym

TRAUMAP

Enrollment

500

Registered

2026-07-06

Start date

2024-10-18

Completion date

2044-10-01

Last updated

2026-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Traumatic Brain Injury

Keywords

traumatic brain injury, contusion, brain resection, biopsy

Brief summary

The TRAUMAP study will function as a brain tissue repository for biopsy specimens from patients with traumatic brain injury undergoing brain surgery for contusion removal.

Detailed description

The TRAUMAP study aims to investigate the molecular and cellular mechanisms underlying secondary brain injury following traumatic brain injury (TBI) through the analysis of surgically resected contused human brain tissue. Tissue specimens will be collected from adult patients undergoing neurosurgical removal of cerebral contusions as part of routine clinical care. No additional procedures will be performed for research purposes, and only tissue that would otherwise be discarded will be used. Brain tissue samples will undergo histological, biochemical, and molecular analyses to investigate pathways involved in neuroinflammation, cell death, neurodegeneration, and endogenous regenerative responses. Molecular findings will be correlated with clinical characteristics to improve the understanding of TBI pathophysiology, validate preclinical observations, and identify potential therapeutic targets for future neuroprotective and regenerative strategies.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults aged ≥18 years. * Diagnosis of traumatic brain injury (TBI). * Admission to the intensive care unit. * Clinical indication for neurosurgical evacuation of a cerebral contusion. * Written informed consent to participate to the study.

Exclusion criteria

* Coagulation disorders or other contraindications to the planned neurosurgical procedure.

Design outcomes

Primary

Measure	Time frame	Description
Tissue Used for Future Research Studies	Time frame as clinically indicated, maximum 2 weeks after TBI	Tissue collected through the study will be stored and used in future approved research studies

Countries

Italy

Contacts

CONTACTElisa R Zanier, MD

elisa.zanier@marionegri.it+390239014204

CONTACTFrancesca Pischiutta, PhD

francesca.pischiutta@marionegri.it+390239014377

Outcome results