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Comparative Effects of Mirror Therapy, Proprioceptive Neuromuscular Facilitation, and Constraint-Induced Movement Therapy on Upper Limb Motor Recovery in Stroke Survivors: A Three-Arm Randomized Controlled Trial

Comparative Effects of Mirror Therapy, Proprioceptive Neuromuscular Facilitation, and Constraint-Induced Movement Therapy on Upper Limb Motor Recovery in Stroke Survivors: A Three-Arm Randomized Controlled Trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07683130
Enrollment
90
Registered
2026-07-06
Start date
2025-07-03
Completion date
2026-01-03
Last updated
2026-07-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Keywords

Stroke, Mirror Therapy, Rehabilitation

Brief summary

This study aimed to compare the effects of these three interventions on upper limb motor recovery in stroke survivors. A three-arm randomized controlled trial was conducted in which eligible participants (N=90) with post-stroke upper limb hemiparesis were randomly allocated into three groups of 30 each: MT group, PNF group, and CIMT group. All groups received their respective interventions alongside conventional physiotherapy, five sessions per week for six weeks.

Detailed description

Stroke remains a leading cause of long-term disability worldwide, with upper limb motor impairment being one of the most prevalent and debilitating consequences. While several neurorehabilitation approaches have demonstrated efficacy individually, limited evidence existed comparing the relative effectiveness of mirror therapy (MT), proprioceptive neuromuscular facilitation (PNF), and constraint-induced movement therapy (CIMT) within a single trial framework. This study aimed to compare the effects of these three interventions on upper limb motor recovery in stroke survivors. A three-arm randomized controlled trial was conducted in which eligible participants (N=90) with post-stroke upper limb hemiparesis were randomly allocated into three groups of 30 each: MT group, PNF group, and CIMT group. All groups received their respective interventions alongside conventional physiotherapy, five sessions per week for six weeks. The outcome measure were the Fugl-Meyer Assessment for Upper Extremity (FMA-UE), Action Research Arm Test (ARAT), Modified Ashworth Scale (MAS) and grip strength via hand-held dynamometry. Assessments were performed at baseline and at after 12 weeks post-intervention.

Interventions

OTHERmirror therapy

Mirror Therapy: Participant in the group were provided mirror therapy for a duration of 12 weeks

OTHERPNF

PNF Group: Participant were given PNF therapy for a total duration of 12 weeks

OTHERConstraint-induced movement therapy

Constraint-induced movement therapy: Participant were given Constraint-induced movement therapy for a total duration of 12 weeks

Sponsors

Foundation of Medical Research and Laboratories, Pakistan
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)

Eligibility

Sex/Gender
ALL
Age
25 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

Stroke Patients Both male and female Age: 25-65 years -

Exclusion criteria

unable to perform exercises Do not provide consent Cognitive Impairment \-

Design outcomes

Primary

MeasureTime frameDescription
Action Research Arm Test12 weeksThe assessment were taken at baseline and after 12 weeks of intervention
Fugl-Meyer Assessment for Upper Extremity12 weeksThe assessment were taken at baseline and after 12 weeks of intervention
Modified Ashworth Scale12 weeksThe assessment were taken at baseline and after 12 weeks of intervention
grip strength via hand-held dynamometry12 weeksThe assessment were taken at baseline and after 12 weeks of intervention

Countries

Pakistan

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 7, 2026