Study on the Association Between Serrated Polyps and Metachronous Advanced Colorectal Neoplastic Lesions

Risk Factors for Metachronous Advanced Colorectal Lesions After Endoscopic Resection of Serrated Lesions

Status

Not yet recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07678788

Enrollment

750

Registered

2026-07-01

Start date

2026-06-01

Completion date

2026-12-01

Last updated

2026-07-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Serrated Polyp, Sessile Serrated Lesion

Brief summary

This study aims to explore the risk factors associated with the development of ACN and same-site ACN in patients with SP, thereby informing the optimization of clinical surveillance strategies

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Inclusion criteria

* Adult patients aged \> 18 years;At least one SP detected during the index colonoscopy and pathologically confirmed as TSA or SSL (according to the 2019 WHO classification criteria);Underwent complete polypectomy during the index colonoscopy;Received regular follow-up at Changhai Hospital, with an interval of ≥ 6 months between the index and follow-up colonoscopies;Complete clinical and pathological data.

Exclusion criteria

* Incomplete colonoscopy or failed cecal intubation;Inadequate bowel preparation, defined as a Boston Bowel Preparation Scale (BBPS) score \< 6 or a score \< 2 in any bowel segment;Withdrawal time \< 6 minutes;Diagnosis of hereditary cancer syndromes, such as familial adenomatous polyposis (FAP) or Lynch syndrome;Concurrent inflammatory bowel disease (IBD) or indeterminate colitis;History of colorectal cancer or other malignancies;Incomplete clinical or pathological records.

Design outcomes

Primary

Measure	Time frame
The occurrence of metachronous ACN	At least 6 months after index colonoscopy

Contacts

CONTACTYu Bai, M.D

19851132340@163.com+8619280762294

Outcome results