Assessment of Left Ventricular Myocardial Dysfunction in Children With End-Stage Kidney Disease Using Two-Dimensional and Three-Dimensional Speckle-Tracking Echocardiography

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07678710

Enrollment

Registered

2026-07-01

Start date

2025-01-01

Completion date

2025-08-01

Last updated

2026-07-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Children, End-Stage Kidney Disease, Left Ventricular Myocardial Dysfunction, Three-Dimensional Speckle-Tracking Echocardiography, Two-Dimensional Speckle-Tracking Echocardiography

Brief summary

The present study aimed to assess left ventricular myocardial dysfunction in children with chronic kidney disease using 2D and 3D speckle-tracking echocardiography.

Detailed description

Chronic kidney disease (CKD) is a complex and multifaceted disease that causes renal dysfunction and progression to end-stage kidney disease. Cardiovascular risk is common in patients with end-stage renal disease on hemodialysis, many studies have shown that the risk of adverse cardiovascular events is significantly increased and persistent in all patients treated with hemodialysis, especially those who have just started hemodialysis treatment. Patients with end-stage renal disease have elevated levels of cardiac biomarkers, despite no apparent signs of cardiac dysfunction or radial damage; this is related to chronic kidney disease comorbidities and reduced renal clearance per se.

Interventions

DEVICETwo-Dimensional Speckle-Tracking Echocardiography (2D-STE)

2D speckle-tracking echocardiography was used to assess left ventricular myocardial deformation. Standard apical four-, two-, and three-chamber views were acquired with optimized frame rates.

DEVICEThree-Dimensional Speckle-Tracking Echocardiography (3D-STE)

Three-dimensional datasets were acquired from apical full-volume images, ensuring optimal electrocardiographic gating, adequate frame rates, and high-quality image acquisition.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

4 Years to 18 Years

Healthy volunteers

Inclusion criteria

* Age between 4 and 18 years. * Children with chronic kidney disease (CKD) receiving regular hemodialysis for ≥1 year.

Exclusion criteria

* Presence of structural or congenital heart disease. * Patients with poor echocardiographic window or arrhythmias interfering with image acquisition.

Design outcomes

Primary

Measure	Time frame	Description
Left ventricular systolic function	At baseline	Left ventricular systolic function was evaluated by calculating the left ventricular ejection fraction (LVEF) using the biplane Simpson's method from apical four- and two-chamber views.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 2, 2026