Cardiac Magnetic Resonance Imaging, Cardiovascular Disease, Neoplasm
Conditions
Keywords
Cardiovascular disease, Malignancy, Cardiac Magnetic Resonance Imaging, Hemodynamic parameters
Brief summary
Cancer and cardiovascular diseases are among the leading causes of morbidity and mortality worldwide. Advanced imaging techniques such as 4D magnetic resonance imaging (MRI) enable quantitative assessment of hemodynamic and functional parameters beyond conventional imaging. The aim of this study is to evaluate the association between 4D MRI derived parameters and the occurrence, severity, and prognosis of major chronic diseases, and to explore their potential role as imaging biomarkers.
Detailed description
This is a single-center, prospective, observational registry study conducted at Ulsan University Hospital. The study will enroll 1,000 adult patients (≥ 19 years) undergoing cardiac MRI as part of routine clinical care in Korea. Participants will undergo an additional 4D MRI sequence during the same imaging session, which does not affect clinical decision-making or patient management. The primary objective of this study is to evaluate the association between quantitative imaging parameters derived from 4D MRI and the occurrence, severity, and prognosis of major chronic diseases.
Interventions
None listed
Sponsors
Ulsan University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Adults aged 19 years and older undergoing clinically indicated Cardiac MRI at Ulsan University Hospital * Participants who undergo an additional 4D MRI sequence during the same imaging session * Participants who are able to understand the study and provide written informed consent
Exclusion criteria
* Individuals aged \< 19 years * Individuals with cognitive impairment or communication difficulties unable to provide informed consent * Poor-quality MRI images that are not suitable for analysis * Individuals deemed inappropriate for study participation by the investigator
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Major Adverse Cardiovascular Events (MACE) | up to 10 years | Incidence of major adverse cardiovascular events, including cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, hospitalization for heart failure during the follow-up period |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Peak Wall Shear Stress | Perioperative/Periprocedural | peak wall shear stress measured in the ascending aorta using 4D flow MRI |
| Blood Flow Eccentricity | Perioperative/Periprocedural | Blood Flow Eccentricity assessed in the ascending aorta using 4D flow MRI |
Countries
South Korea
Contacts
CONTACTGyung-Min Park MD, PhD
Outcome results
None listed