Functional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational Study

Functional Muscle-Bone Incongruity Index (FKUI): Combined Evaluation of Handgrip Strength, Total Hip Bone Mineral Density, and Lumbar-Hip Bone Mineral Density Discordance in Adults Undergoing DXA

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07677033

Acronym

FKUI

Enrollment

200

Registered

2026-06-30

Start date

2026-05-01

Completion date

2027-05-01

Last updated

2026-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Musculoskeletal Health, Osteopenia, Osteoporosis, Sarcopenia

Keywords

Functional Muscle-Bone Incongruity Index FKUI, FKUI, Bone Mineral Density, Hip-Spine Discordance, Handgrip Strength

Brief summary

The Functional Muscle-Bone Incongruity Index (FKUI) is a novel approach developed to evaluate the relationship between muscle function and bone health. This prospective observational study aims to investigate the clinical applicability of FKUI, which combines handgrip strength, total hip bone mineral density (BMD), and lumbar-hip BMD discordance. Approximately 200 adult participants undergoing routine DXA assessment will be enrolled. The study will examine whether the combined evaluation of muscle function and bone health parameters provides a more comprehensive assessment of musculoskeletal status than individual measures alone.

Detailed description

This is a prospective, observational, single-center study evaluating adults undergoing routine DXA assessment in a Physical Medicine and Rehabilitation outpatient clinic. The study will investigate the clinical applicability of the Functional Muscle-Bone Incongruity Index (FKUI), a composite approach based on handgrip strength, total hip bone mineral density, and lumbar-hip bone mineral density discordance. No treatment or interventional procedure will be administered as part of the study. Handgrip strength will be measured using a calibrated hand dynamometer, and DXA-derived bone mineral density values will be recorded from routine clinical assessments. The study aims to determine whether the combined evaluation of muscle function and bone health parameters may provide a more comprehensive assessment of musculoskeletal status.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age 18 years or older * Attendance at the Physical Medicine and Rehabilitation outpatient clinic * Scheduled to undergo routine bone mineral density assessment by DXA as part of clinical evaluation * Ability to perform handgrip strength testing * Availability of lumbar spine and total hip bone mineral density measurements suitable for analysis * Ability and willingness to provide written informed consent

Design outcomes

Primary

Measure	Time frame	Description
Functional Muscle-Bone Incongruity Index (FKUI)	Baseline (at study enrollment)	Assessment of the clinical applicability of the Functional Muscle-Bone Incongruity Index (FKUI), a composite index based on handgrip strength, total hip bone mineral density, and lumbar-hip bone mineral density discordance.

Countries

Turkey (Türkiye)

Contacts

CONTACTDilek Ün Oğuzhanasiltürk, MD

dilekunoguzhan@gmail.com+90 5056367184

Outcome results