PET-CT
Conditions
Brief summary
Differentiating radiation necrosis from tumor progression in patients with brain metastases has a major therapeutic and prognostic implications
Detailed description
Differentiating radiation necrosis from tumor progression in patients with brain metastases treated with radiotherapy is a major challenge in post-treatment management, as the therapeutic and prognostic implications differ substantially depending on whether the lesion represents radiation necrosis (surveillance, anti-angiogenic therapy) or tumor progression (re-initiation of local or systemic treatment). In addition to brain MRI, amino acid PET imaging, including both static and dynamic acquisitions, is a key diagnostic tool for this purpose. However, the added value of dynamic acquisitions remains uncertain, and the available evidence is limited to small patient series.
Interventions
DIAGNOSTIC_TESTPET exam analysis
static and dynamic analyses
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
OTHER
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* Patients who received a PET amino acid for differentiating radiation necrosis from progression of irradiated brain metastases,
Exclusion criteria
* Patients who refused the using of their data
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| To compare the diagnostic performance amino acid PET imaging | Day 1 | Uptake of tumor |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| To evaluate the potential impact of immunotherapy administered before or during PET imaging | 2 weeks | MRI results |
Contacts
CONTACTLucas LW WILHELM, MD
CONTACTVeronique VR Roch, MSc
PRINCIPAL_INVESTIGATORAntoine AV VERGER, MD, PhD
NANCY HOSPITAL
Outcome results
None listed