Impact of Intracanal Cryotherapy and Corticosteroids on Post Endodontic Pain

Efficiency Of Intracanal Cryotherapy Versus Corticosteroids As Final Irrigation On Post Operative Pain Level In Patients With Symptomatic Irreversible Pulpitis Randomized Control Trial

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07676396

Enrollment

Registered

2026-06-30

Start date

2025-04-01

Completion date

2026-03-01

Last updated

2026-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptomatic Irreversible Pulpitis (SIP)

Keywords

pain, cryotherapy, postoperative pain, dexamethasone, cold saline

Brief summary

The aim of the study: is to evaluate efficiency of using either intracanal corticosteroids or intracanal cryotherapy as a final flush irrigation on post endodontic pain in lower molar teeth with symptomatic irreversible pulpitis. The materials and methods: In this study forty patients with symptomatic irreversible pulpitis in lower molar teeth with pain level of 4 or higher on the visual analogue scale (VAS) will be selected.

Detailed description

This study will involve 40 adult patients (18-60 years) for both genders equally .all of patients must provide written informed consent and commit to the full trial period. Eligible participants must present with a lower molar diagnosed with symptomatic irreversible pulpitis, characterized by moderate-to-severe preoperative pain (VAS score ≥ 4) that lingers after stimulus removal. Conversely, the study excludes vulnerable groups (e.g., pregnant or mentally ill), medically compromised individuals, and those who have taken analgesics or antibiotics. Specific dental exclusions include teeth with open apices, calcified canals, prior endodontic treatment, or periodontally affected tooth

Interventions

DRUGdexamethasone

intra root canal final flush of 5ml of 4mg/ml dexamethasone before obturation

OTHERCold Saline

intra root canal final flush of 20ml of cold saline before obturation

OTHERcold sodium hypochlorite

intra root canal final flush of 20ml of cold sodium hypochlorite before obturation

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

18 Years to 60 Years

Healthy volunteers

Yes

Inclusion criteria

* both gender - * age range of (18-60 years ) -medical free patients with lower molars with symptomatic irreversible pulpitis and indicated for single visit root canal treatment with pain score 4 or more on VAS- Patients that commit for the entire period of the trial and agreed to sign the informed consent .

Exclusion criteria

* vulnerable group -teeth with open apex or calcified canals-curved canals- * patients on analgesics or antibiotics * periodontaly affected tooth

Design outcomes

Primary

Measure	Time frame	Description
postoperative pain	1 year	assessment of post operative pain after single visit root canal treatment using vasual analogue scale

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 1, 2026