Risk Factors for PICC-Related Infection in 994 High-Risk Patients: The Role of Hb Levels and Sampling Frequency

Risk Factors for PICC-Related Infection in 994 High-Risk Patients: The Role of Hb Levels and Sampling Frequency-A Retrospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07674992

Enrollment

1239

Registered

2026-06-30

Start date

2023-01-01

Completion date

2026-04-01

Last updated

2026-06-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

CLABSI - Central Line Associated Bloodstream Infection

Keywords

Catheters, Peripherally Inserted Central; Catheter-Related Infections, CLABSI, Hemoglobin threshold, Risk factors

Brief summary

This retrospective cohort study aims to evaluate the incidence and clinical predictors of Central Line-Associated Bloodstream Infections (CLABSI) in patients receiving Peripherally Inserted Central Catheters (PICCs) via the Anesthesia Department.

Interventions

OTHERHemoglobin level

Hb ≤ 9.6 g/dL

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patient with PICC line more than 48 hours, performed by Anesthesia Department from January 2023 to December 2024

Exclusion criteria

* Incomplete data * Patient with reported colonization of PICC line * Patient with unintended position of PICC line * Patient with any other central venous catheter besides PICC line * Patient with previously reported as CLABSI

Design outcomes

Primary

Measure	Time frame	Description
rate of CLABSI	From January 2023 to December 2024	incidence of CLABSI

Secondary

Measure	Time frame	Description
Study the risk factors related to CLABSI, including clinical factors, comorbidities, indication for PICC, and laboratory.	From January 2023 to December 2024	To evaluate potential risk factors for CLABSI, baseline demographic, clinical, and procedural characteristics will be collected at PICC line insertion and analyzed using two aggregated formats: continuous variables will be reported as means (with SD) or medians (with IQR): age (years), weight (kg), height (m), combined BMI (kg/m\^2), procedure duration (minutes), catheter indwelling time (days), hemoglobin (g/dL), and white blood cell counts (cells/µL). Categorical variables will be reported as percentages/proportions: sex, ICU admission, preprocedural antibiotics, procedure duration \<60 minutes, indwelling time ≤6 weeks, comorbidities (immunocompromised, hypertension, liver disease, diabetes, oncologic/hematologic malignancies), and insertion indications (TPN, CMT, prolonged IV meds, frequent blood sampling, vasopressors). All variables will be analyzed via regression to identify independent predictors of CLABSI.

Countries

Thailand

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 1, 2026