Aging, Menopause, Women
Conditions
Brief summary
To determine if vascular beta3 adrenergic receptors are present and functional in aging women and can be targeted to attenuate sympathetic vasoconstriction and enhance vascular function in aging women.
Interventions
DRUGPlacebo
Participants will receive a placebo in pill form.
DRUGGemtesa
Participants will receive oral gemtesa (75 mg).
Sponsors
University of Missouri-Columbia
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy women, * Assigned female at birth, * 18-70 years of age, * Body mass index \<18 or ≥30 kg/m2,
Exclusion criteria
* Assigned male at birth, * Pregnancy, * Breastfeeding, * History of hormone replacement therapy, chemical menopause, or oophor-ectomy * Polycystic ovarian syndrome or Primary ovarian insufficiency, * Current smoking/Nicotine use, * Blood pressure ≥140/90 mmHg, * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy, * Nerve/neurologic disease, * Cardiovascular, hepatic, renal, respiratory disease, * Hypersensitivity to nitroglycerin, * Diabetes, * Communication barriers,
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood flow | Change from baseline to minute 2. | Blood flow measured with Doppler ultrasound. |
Countries
United States
Contacts
CONTACTJacqueline Limberg Associate Professor
Outcome results
None listed