Postoperative Cognitive Dysfunction
Conditions
Brief summary
This study aims to explore the effect of ciprofol on the postoperative cognitive function of inpatients undergoing gastrointestinal endoscopy examination, to compare the anesthetic effects and differences in adverse reactions of propofol and ciprofol in gastrointestinal endoscopy , to compare the incidence of postoperative cognitive decline in patients undergoing gastrointestinal endoscopy examination between propofol and coprofol, and to optimize the anesthesia medication regimen for patients undergoing gastrointestinal endoscopy examination.
Interventions
DRUGCiprofol group
patients in the Ciprofol group will use ciprofol to complete the painless gastroscopy and colonoscopy treatment.
DRUGPropofol group
patients in the propofol group will use propofol to complete the painless gastroscopy and colonoscopy treatment.
Sponsors
The Second Affiliated Hospital of Chongqing Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age: 18-65 years old, ASA grade I-Ⅲ, BMI index: 18.5-30 kg/m ² 2. Patients who plan to undergo gastroscopy or colonoscopy in our hospital 3. The preoperative assessment of the MOCA scale in patients scheduled for elective surgery indicated normal cognitive function 4. dextromanuality 5. Voluntarily participate in this study and sign the informed consent form
Exclusion criteria
1. Pregnant or lactating women 2. Patients who have had cardiovascular and cerebrovascular accidents in the past 3. Patients with severe diseases of the cardiovascular system, respiratory system and liver and kidney system 4. Patients with obstructive sleep apnea syndrome 5. Patients with concurrent neurological or mental system diseases, or those with incomplete intellectual development 6. Patients allergic to ciprofol or propofol drugs 7. Patients with braking, visual/auditory impairments 8. Patients with psychotropic drug addiction or alcohol dependence 9. Patients who themselves or their attending physicians refused to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in the incidence of cognitive function decline between ciprofol and propofol in patients undergoing painless gastroscopy and colonoscopy treatment | From the time the patient was enrolled in the study to 24 hours after the treatment |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Intraoperative and postoperative adverse events | From the time the patient enters the operating room to 24 hours after the treatment | — |
| Blood Pressure (mmHg) | From entering the operating room to leaving it (before anesthesia, after induction, and 5 minutes、10 minutes 、20 minutes 、30 minutes 、40 minutes、50 minutes、60 minutes after the operation began) | Non-invasive BP measured by cuff after entry and intermittently during surgery. Hypotension: SBP decrease \>30% from baseline; Hypertension: SBP increase \>30% from baseline. |
| Heart Rate (beats/min) | From entering the operating room to leaving it (before anesthesia, after induction, and 5 minutes、10 minutes 、20 minutes 、30 minutes 、40 minutes、50 minutes、60 minutes after the operation began) | Read from monitor. Bradycardia: \<50 bpm or decrease ≥25% from baseline; Tachycardia: \>100 bpm or increase ≥25% from baseline. |
| Respiratory Rate (breaths/min) | From entering the operating room to leaving it (before anesthesia, after induction, and 5 minutes、10 minutes 、20 minutes 、30 minutes 、40 minutes、50 minutes、60 minutes after the operation began) | Read from monitor or counted over 1 min. Respiratory depression: \<8 breaths/min lasting \>30 sec. |
| Oxygen Saturation (Pulse Oximetry) | From entering the operating room to leaving it (before anesthesia, after induction, and 5 minutes、10 minutes 、20 minutes 、30 minutes 、40 minutes、50 minutes、60 minutes after the operation began) | Read from monitor. Hypoxemia: SpO2 \<90% lasting \>15 sec. |
Countries
China
Contacts
STUDY_DIRECTORGuangyou Duan
The Second Affiliated Hospital of Chongqing Medical University
Outcome results
None listed