Perioperative Antibiotic Exposure and Postoperative Delirium in Older Adults Undergoing Elective Non-cardiac Surgery: A Single-center Prospective Cohort Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07673510

Enrollment

4711

Registered

2026-06-29

Start date

2020-04-01

Completion date

2026-05-01

Last updated

2026-06-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Delirium - Postoperative

Brief summary

This study aimed to characterize the current patterns of perioperative prophylactic antibiotic use and to systematically evaluate the association between different antibiotic classes and the occurrence of POD, thereby providing clinically relevant safety evidence for perioperative antibiotic decision-making and delirium prevention strategies.

Detailed description

This prospective, observational, single-center cohort analysis was a substudy of the Perioperative Database of Chinese Elderly Patients (PDCEP) study.

Interventions

DRUGPerioperative antibiotics exposure

Antimicrobial exposure was defined as a record of antibiotic use prior to the occurrence of delirium. Antimicrobials were divided into five non-mutually exclusive groups: beta-lactams (subclasses: first- through fourth-generation cephalosporins, penicillins and carbapenems), nitroimidazoles, glycopeptides, fluoroquinolones, and others (subclasses: aminoglycosides, oxazolidinones, antifungals, lincosamides, macrolides, and fosfomycins).

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients over 65 years old * patients undergoing elective non-cardiac surgery

Exclusion criteria

* older adult patients who had history of psychotic disorders * history of neurological disease * conditions that would make assessments for delirium unreliable * preoperative infection * severe hepatic and renal dysfunction, minor and intermediate clean-incision surgery * missing data exceeding 5%, and no medication records

Design outcomes

Primary

Measure	Time frame	Description
Incidence of postoperative delirium	Participants will be followed for the duration of hospital stay, an expected average of 7 days.	Evaluations are conducted twice a day.

Countries

China

Contacts

PRINCIPAL_INVESTIGATORHao Li

Chinese PLA General Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 30, 2026